Perceptions of research bronchoscopy in Malawian adults with pulmonary tuberculosis: a cross-sectional study

Andrew D. McCallum, Deborah Nyirenda, Wezzie Lora, Saye H. Khoo, Derek J. Sloan, Henry C. Mwandumba, Nicola Desmond, Geraint R. Davies

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Bronchoscopy is an established research tool in Malawi, enabling collection of pulmonary samples for immunological, pharmacological, and microbiological studies. It is, however, an invasive clinical procedure that offers no direct benefit to volunteering participants when used in a research capacity alone, and thus informed consent is essential. This study aimed to explore TB patients' understanding of research bronchoscopy, what would motivate them to participate in research bronchoscopy, and their concerns, in order to inform consenting processes for future clinical studies. We used a qualitative research design. Two focus group discussions were conducted with community members and TB patients to understand their perceptions of bronchoscopy. Transcripts were coded by multiple coauthors and thematic content analysis was used to analyse main findings. We found that Malawian patients with pulmonary TB were willing to participate in a study using research bronchoscopy for health assessment and access to improved healthcare. We identified information of value to potential participants when consenting to that may lessen some of the anxieties expressed by participants. Patient and public involvement is essential to improve informed consent and institutional trust.
Original languageEnglish
Article numbere0165734
Pages (from-to)1-12
Number of pages12
JournalPLoS ONE
Issue number10
Publication statusPublished - 31 Oct 2016


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