Peptide hydrogen-bonded organic frameworks

Thangavel Vijayakanth; Sneha Dasgupta; Pragati Ganatra; Sigal Rencus-Lazar; Aamod V. Desai; Shyamapada Nandi; Rahul Jain; Santu Bera; Andy I. Nguyen; Ehud Gazit; Rajkumar Misra

doi:10.1039/d3cs00648d

Peptide hydrogen-bonded organic frameworks

Thangavel Vijayakanth^*, Sneha Dasgupta, Pragati Ganatra, Sigal Rencus-Lazar, Aamod V. Desai, Shyamapada Nandi, Rahul Jain, Santu Bera, Andy I. Nguyen^*, Ehud Gazit^*, Rajkumar Misra^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Review article › peer-review

Abstract

Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.

Original language	English
Journal	Chemical Society Reviews
Early online date	7 Mar 2024
DOIs	https://doi.org/10.1039/d3cs00648d
Publication status	E-pub ahead of print - 7 Mar 2024

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@article{919e9b87a1064801b2747e5a05ff57be,

title = "Peptide hydrogen-bonded organic frameworks",

abstract = "Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.",

author = "Thangavel Vijayakanth and Sneha Dasgupta and Pragati Ganatra and Sigal Rencus-Lazar and Desai, {Aamod V.} and Shyamapada Nandi and Rahul Jain and Santu Bera and Nguyen, {Andy I.} and Ehud Gazit and Rajkumar Misra",

note = "This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499) from the Department of Science and Technology, New Delhi. R. M. is also thankful to the National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, for providing the research facilities. T. V. thanks Tel Aviv University for the postdoctoral fellowship. E. G. thanks European Research Council PoC project PepZoPower (101101071). A. I. N. thanks the American Chemical Society Petroleum Research Fund (62285-DNI). S. B. thanks SERB, Govt. of India, for the Ramanujan Fellowship (Ref. no. RJF/2022/000042), and Ashoka University, Sonipat, Haryana, for the infrastructure. S. N. acknowledges Vellore Institute of Technology Chennai for the funding and infrastructure.",

year = "2024",

month = mar,

day = "7",

doi = "10.1039/d3cs00648d",

language = "English",

journal = "Chemical Society Reviews",

issn = "0306-0012",

publisher = "Royal Society of Chemistry",

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T1 - Peptide hydrogen-bonded organic frameworks

AU - Vijayakanth, Thangavel

AU - Dasgupta, Sneha

AU - Ganatra, Pragati

AU - Rencus-Lazar, Sigal

AU - Desai, Aamod V.

AU - Nandi, Shyamapada

AU - Jain, Rahul

AU - Bera, Santu

AU - Nguyen, Andy I.

AU - Gazit, Ehud

AU - Misra, Rajkumar

N1 - This research was supported by the DST Inspire Faculty Fellowship (No. DST/INSPIRE/04/2020/002499) from the Department of Science and Technology, New Delhi. R. M. is also thankful to the National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, for providing the research facilities. T. V. thanks Tel Aviv University for the postdoctoral fellowship. E. G. thanks European Research Council PoC project PepZoPower (101101071). A. I. N. thanks the American Chemical Society Petroleum Research Fund (62285-DNI). S. B. thanks SERB, Govt. of India, for the Ramanujan Fellowship (Ref. no. RJF/2022/000042), and Ashoka University, Sonipat, Haryana, for the infrastructure. S. N. acknowledges Vellore Institute of Technology Chennai for the funding and infrastructure.

PY - 2024/3/7

Y1 - 2024/3/7

N2 - Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.

AB - Hydrogen-bonded porous frameworks (HPFs) are versatile porous crystalline frameworks with diverse applications. However, designing chiral assemblies or biocompatible materials poses significant challenges. Peptide-based hydrogen-bonded porous frameworks (P-HPFs) are an exciting alternative to conventional HPFs due to their intrinsic chirality, tunability, biocompatibility, and structural diversity. Flexible, ultra-short peptide-based P-HPFs (composed of 3 or fewer amino acids) exhibit adaptable porous topologies that can accommodate a variety of guest molecules and capture hazardous greenhouse gases. Longer, folded peptides present challenges and opportunities in designing P-HPFs. This review highlights recent developments in P-HPFs using ultra-short peptides, folded peptides, and foldamers, showcasing their utility for gas storage, chiral recognition, chiral separation, and medical applications. It also addresses design challenges and future directions in the field.

U2 - 10.1039/d3cs00648d

DO - 10.1039/d3cs00648d

M3 - Review article

SN - 0306-0012

JO - Chemical Society Reviews

JF - Chemical Society Reviews

ER -

Peptide hydrogen-bonded organic frameworks

Abstract

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