[Pd(mu-Cl)Cl(IPr*)](2): a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling

Mathieu Lesieur; Alexandra M. Z. Slawin; Catherine S. J. Cazin

doi:10.1039/c4ob01269k

[Pd(mu-Cl)Cl(IPr*)](2): a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling

Mathieu Lesieur, Alexandra M. Z. Slawin, Catherine S. J. Cazin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The new well-defined catalyst [Pd(mu-Cl)Cl(IPr*)](2) enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.

Original language	English
Pages (from-to)	5586-5589
Number of pages	4
Journal	Organic & Biomolecular Chemistry
Volume	12
Issue number	30
DOIs	https://doi.org/10.1039/c4ob01269k
Publication status	Published - 14 Aug 2014

Keywords

N-HETEROCYCLIC CARBENE
SUZUKI-MIYAURA COUPLINGS
ARYL CHLORIDES
LIGANDS
COORDINATION
FLEXIBILITY
COMPLEXES
HALIDES
NHC

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10.1039/c4ob01269k

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title = "[Pd(mu-Cl)Cl(IPr*)](2): a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling",

abstract = "The new well-defined catalyst [Pd(mu-Cl)Cl(IPr*)](2) enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.",

keywords = "N-HETEROCYCLIC CARBENE, SUZUKI-MIYAURA COUPLINGS, ARYL CHLORIDES, LIGANDS, COORDINATION, FLEXIBILITY, COMPLEXES, HALIDES, NHC",

author = "Mathieu Lesieur and Slawin, \{Alexandra M. Z.\} and Cazin, \{Catherine S. J.\}",

year = "2014",

month = aug,

day = "14",

doi = "10.1039/c4ob01269k",

language = "English",

volume = "12",

pages = "5586--5589",

journal = "Organic \& Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "30",

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T1 - [Pd(mu-Cl)Cl(IPr*)](2): a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling

AU - Lesieur, Mathieu

AU - Slawin, Alexandra M. Z.

AU - Cazin, Catherine S. J.

PY - 2014/8/14

Y1 - 2014/8/14

N2 - The new well-defined catalyst [Pd(mu-Cl)Cl(IPr*)](2) enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.

AB - The new well-defined catalyst [Pd(mu-Cl)Cl(IPr*)](2) enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.

KW - N-HETEROCYCLIC CARBENE

KW - SUZUKI-MIYAURA COUPLINGS

KW - ARYL CHLORIDES

KW - LIGANDS

KW - COORDINATION

KW - FLEXIBILITY

KW - COMPLEXES

KW - HALIDES

KW - NHC

UR - https://www.scopus.com/pages/publications/84904012321

U2 - 10.1039/c4ob01269k

DO - 10.1039/c4ob01269k

M3 - Article

SN - 1477-0520

VL - 12

SP - 5586

EP - 5589

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 30

ER -

[Pd(mu-Cl)Cl(IPr*)](2): a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling

Abstract

Keywords

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