[Pd(mu-Cl)Cl(IPr*)](2): a highly hindered pre-catalyst for the synthesis of tetra-ortho-substituted biaryls via Grignard reagent cross-coupling

Mathieu Lesieur, Alexandra M. Z. Slawin, Catherine S. J. Cazin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The new well-defined catalyst [Pd(mu-Cl)Cl(IPr*)](2) enables the efficient Grignard reagent cross-coupling for the synthesis of tetra-ortho-substituted biaryls. The high reactivity of the complex is associated with the important bulkiness of the IPr* ligand. The dimer represents the most efficient catalyst reported to date for this challenging transformation.

Original languageEnglish
Pages (from-to)5586-5589
Number of pages4
JournalOrganic & Biomolecular Chemistry
Volume12
Issue number30
DOIs
Publication statusPublished - 14 Aug 2014

Keywords

  • N-HETEROCYCLIC CARBENE
  • SUZUKI-MIYAURA COUPLINGS
  • ARYL CHLORIDES
  • LIGANDS
  • COORDINATION
  • FLEXIBILITY
  • COMPLEXES
  • HALIDES
  • NHC

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