Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system

Ahmed B. M. Ibrahim; Ghada Abd-Elmonsef Mahmoud; David B. Cordes; Alexandra M. Z. Slawin

doi:10.1002/aoc.6798

Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system

Ahmed B. M. Ibrahim^*, Ghada Abd-Elmonsef Mahmoud, David B. Cordes, Alexandra M. Z. Slawin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Pb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L¹)₂] 1, [Pb(L²)₂] 2, [Hg(L¹)₂] 3 and [Hg(L²)₂] 4; HL¹ = 4-(4-nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL² = 4-(2-chlorophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}. The solid-state structures of complexes 2 and 3 were determined by X-ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1-4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes giving rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited Cladosporium sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD) and catalase (CAT) activities dependent on their concentrations.

Original language	English
Article number	e6798
Number of pages	11
Journal	Applied Organometallic Chemistry
Volume	36
Issue number	8
Early online date	28 Jun 2022
DOIs	https://doi.org/10.1002/aoc.6798
Publication status	Published - 12 Jul 2022

Keywords

NNS ligands
Heavy metals
Pathogen
Catalase
Superoxide dismutase

Access to Document

10.1002/aoc.6798

Ibrahim_2022_AOC_Pb-II-and-Hg-II-Thiosemicarbazones_AAM
Copyright © 2022 John Wiley & Sons Ltd.This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/aoc.6798
Accepted author manuscript, 1.46 MB

CCDC 2127785 & 2127786: Experimental Crystal Structure Determination
Ibrahim (Creator), Ahmed B., M. (Creator), Mahmoud (Creator), Ghada A., -E. (Creator), Cordes (Creator), David, B. (Creator), Slawin (Creator) & Alexandra M., Z. (Creator), Cambridge Crystallographic Data Centre, 2022
DOI: 10.5517/ccdc.csd.cc29f474, https://dx.doi.org/10.5517/ccdc.csd.cc29f485
Dataset

Cite this

@article{49aa8e8b1bc343cdbc9f480e99079d53,

title = "Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system",

abstract = "Pb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L1)2] 1, [Pb(L2)2] 2, [Hg(L1)2] 3 and [Hg(L2)2] 4; HL1 = 4-(4-nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL2 = 4-(2-chlorophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}. The solid-state structures of complexes 2 and 3 were determined by X-ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1-4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes giving rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited Cladosporium sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD) and catalase (CAT) activities dependent on their concentrations.",

keywords = "NNS ligands, Heavy metals, Pathogen, Catalase, Superoxide dismutase",

author = "Ibrahim, {Ahmed B. M.} and Mahmoud, {Ghada Abd-Elmonsef} and Cordes, {David B.} and Slawin, {Alexandra M. Z.}",

year = "2022",

month = jul,

day = "12",

doi = "10.1002/aoc.6798",

language = "English",

volume = "36",

journal = "Applied Organometallic Chemistry",

issn = "0268-2605",

publisher = "John Wiley & Sons, Ltd",

number = "8",

}

Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system. / Ibrahim, Ahmed B. M.; Mahmoud, Ghada Abd-Elmonsef; Cordes, David B. et al.
In: Applied Organometallic Chemistry, Vol. 36, No. 8, e6798, 12.07.2022.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system

AU - Ibrahim, Ahmed B. M.

AU - Mahmoud, Ghada Abd-Elmonsef

AU - Cordes, David B.

AU - Slawin, Alexandra M. Z.

PY - 2022/7/12

Y1 - 2022/7/12

N2 - Pb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L1)2] 1, [Pb(L2)2] 2, [Hg(L1)2] 3 and [Hg(L2)2] 4; HL1 = 4-(4-nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL2 = 4-(2-chlorophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}. The solid-state structures of complexes 2 and 3 were determined by X-ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1-4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes giving rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited Cladosporium sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD) and catalase (CAT) activities dependent on their concentrations.

AB - Pb (II) and Hg (II) ions were reacted in aqueous solution with two tridentate thiosemicarbazones, resulting in four complexes {[Pb(L1)2] 1, [Pb(L2)2] 2, [Hg(L1)2] 3 and [Hg(L2)2] 4; HL1 = 4-(4-nitrophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide and HL2 = 4-(2-chlorophenyl)-1-((pyridin-2-yl)methylene)thiosemicarbazide}. The solid-state structures of complexes 2 and 3 were determined by X-ray crystallography, which also confirmed the monobasic tridentate NNS nature of the ligands, and the octahedral coordination geometry around the metal centers. Complexes 1-4 exhibited high antifungal activity against the pathogen Cladosporium sphaerospermum; all four complexes giving rise to a reduction in the fungal dry mass and sugar consumption. Complexes 2 and 4 that inhibited Cladosporium sphaerospermum growth at the concentration of 1.8 mM are more efficient inhibitors than the free ligand and metal ions. Further, the complexes gave varied values of the fungal total antioxidants (TA), superoxide dismutase (SOD) and catalase (CAT) activities dependent on their concentrations.

KW - NNS ligands

KW - Heavy metals

KW - Pathogen

KW - Catalase

KW - Superoxide dismutase

U2 - 10.1002/aoc.6798

DO - 10.1002/aoc.6798

M3 - Article

SN - 0268-2605

VL - 36

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 8

M1 - e6798

ER -

Pb (II) and Hg (II) thiosemicarbazones for inhibiting the broad-spectrum pathogen Cladosporium sphaerospermum ASU18 (MK387875) and altering its antioxidant system

Abstract

Keywords

Access to Document

Fingerprint

Datasets

CCDC 2127785 & 2127786: Experimental Crystal Structure Determination

Cite this