Pattern of primary tuberculosis drug resistance and associated treatment outcomes in Transnistria, Moldova

O Dolgusev; N Obevzenco; O Padalco; S Pankrushev; A Ramsay; R Van den Bergh; M Manzi; O Denisiuk; R Zachariah

doi:10.5588/pha.14.0043

Pattern of primary tuberculosis drug resistance and associated treatment outcomes in Transnistria, Moldova

O Dolgusev, N Obevzenco, O Padalco, S Pankrushev, A Ramsay, R Van den Bergh, M Manzi, O Denisiuk, R Zachariah

School of Medicine

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Abstract

This cohort study assessed drug susceptibility testing (DST) patterns and associated treatment outcomes from Transnistria, Moldova, from 2009 to 2012. Of 1089 newly registered tuberculosis (TB) patients with available DST results, 556 (51%) had some form of drug resistance, while 369 (34%) had multidrug-resistant TB (MDR-TB). There were four cases of extensively drug-resistant TB. MDR-TB patients had poor treatment success (45%); human immunodeficiency virus positivity and a history of incarceration were associated with an unfavourable treatment outcome. This first study from Trans-nistria shows a high level of drug-resistant TB, which constitutes a major public health problem requiring urgent attention.

Original language	English
Pages (from-to)	S64-6
Journal	Public health action
Volume	4
Issue number	Suppl 2
DOIs	https://doi.org/10.5588/pha.14.0043
Publication status	Published - 21 Oct 2014

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title = "Pattern of primary tuberculosis drug resistance and associated treatment outcomes in Transnistria, Moldova",

abstract = "This cohort study assessed drug susceptibility testing (DST) patterns and associated treatment outcomes from Transnistria, Moldova, from 2009 to 2012. Of 1089 newly registered tuberculosis (TB) patients with available DST results, 556 (51\%) had some form of drug resistance, while 369 (34\%) had multidrug-resistant TB (MDR-TB). There were four cases of extensively drug-resistant TB. MDR-TB patients had poor treatment success (45\%); human immunodeficiency virus positivity and a history of incarceration were associated with an unfavourable treatment outcome. This first study from Trans-nistria shows a high level of drug-resistant TB, which constitutes a major public health problem requiring urgent attention.",

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AU - Dolgusev, O

AU - Obevzenco, N

AU - Padalco, O

AU - Pankrushev, S

AU - Ramsay, A

AU - Van den Bergh, R

AU - Manzi, M

AU - Denisiuk, O

AU - Zachariah, R

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N2 - This cohort study assessed drug susceptibility testing (DST) patterns and associated treatment outcomes from Transnistria, Moldova, from 2009 to 2012. Of 1089 newly registered tuberculosis (TB) patients with available DST results, 556 (51%) had some form of drug resistance, while 369 (34%) had multidrug-resistant TB (MDR-TB). There were four cases of extensively drug-resistant TB. MDR-TB patients had poor treatment success (45%); human immunodeficiency virus positivity and a history of incarceration were associated with an unfavourable treatment outcome. This first study from Trans-nistria shows a high level of drug-resistant TB, which constitutes a major public health problem requiring urgent attention.

AB - This cohort study assessed drug susceptibility testing (DST) patterns and associated treatment outcomes from Transnistria, Moldova, from 2009 to 2012. Of 1089 newly registered tuberculosis (TB) patients with available DST results, 556 (51%) had some form of drug resistance, while 369 (34%) had multidrug-resistant TB (MDR-TB). There were four cases of extensively drug-resistant TB. MDR-TB patients had poor treatment success (45%); human immunodeficiency virus positivity and a history of incarceration were associated with an unfavourable treatment outcome. This first study from Trans-nistria shows a high level of drug-resistant TB, which constitutes a major public health problem requiring urgent attention.

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DO - 10.5588/pha.14.0043

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SP - S64-6

JO - Public health action

JF - Public health action

IS - Suppl 2

ER -

Pattern of primary tuberculosis drug resistance and associated treatment outcomes in Transnistria, Moldova

Abstract

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