Pathogenomics of non-pathogens

Matthew Holden; Lisa Crossman; Ana Cerdeño-Tárraga; Julian Parkhill

doi:10.1038/nrmicro825

Pathogenomics of non-pathogens

Matthew Holden^*
, Lisa Crossman
, Ana Cerdeño-Tárraga
, Julian Parkhill

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate

Abstract

Analysing the genomes of non-pathogenic microorganisms, in addition to its basic and applied scientific interest, can also shed considerable light on the study of pathogenic microorganisms. Two of the three microorganisms described here are rarely pathogenic, but carry genetic determinants that have previously been identified as being important for the pathogenicity of other microorganisms. This underlines the growing understanding that many so-called 'virulence genes' are probably involved in more general interactions between the microorganism and the host or the environment.

Original language	English
Pages (from-to)	91
Number of pages	1
Journal	Nature Reviews Microbiology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1038/nrmicro825
Publication status	Published - Feb 2004

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title = "Pathogenomics of non-pathogens",

abstract = "Analysing the genomes of non-pathogenic microorganisms, in addition to its basic and applied scientific interest, can also shed considerable light on the study of pathogenic microorganisms. Two of the three microorganisms described here are rarely pathogenic, but carry genetic determinants that have previously been identified as being important for the pathogenicity of other microorganisms. This underlines the growing understanding that many so-called 'virulence genes' are probably involved in more general interactions between the microorganism and the host or the environment.",

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AU - Crossman, Lisa

AU - Cerdeño-Tárraga, Ana

AU - Parkhill, Julian

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N2 - Analysing the genomes of non-pathogenic microorganisms, in addition to its basic and applied scientific interest, can also shed considerable light on the study of pathogenic microorganisms. Two of the three microorganisms described here are rarely pathogenic, but carry genetic determinants that have previously been identified as being important for the pathogenicity of other microorganisms. This underlines the growing understanding that many so-called 'virulence genes' are probably involved in more general interactions between the microorganism and the host or the environment.

AB - Analysing the genomes of non-pathogenic microorganisms, in addition to its basic and applied scientific interest, can also shed considerable light on the study of pathogenic microorganisms. Two of the three microorganisms described here are rarely pathogenic, but carry genetic determinants that have previously been identified as being important for the pathogenicity of other microorganisms. This underlines the growing understanding that many so-called 'virulence genes' are probably involved in more general interactions between the microorganism and the host or the environment.

UR - https://www.scopus.com/pages/publications/8544256328

U2 - 10.1038/nrmicro825

DO - 10.1038/nrmicro825

M3 - Comment/debate

C2 - 15040257

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SN - 1740-1526

VL - 2

SP - 91

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 2

ER -

Pathogenomics of non-pathogens

Abstract

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