Pathogenesis of pneumococcal infection

S. H. Gillespie*, I. Balakrishnan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

55 Citations (Scopus)


The pathogenesis of pneumococcal infection is a complex interplay between pneumococcal virulence determinants and the host immune response. Molecular studies have considerably advanced our knowedge and understanding of the precise structures and functions of the different determinants and their pathogenic roles. This review describes the mechanisms by which pneumococci attach, invade, evade lung defences and cause severe disease. Better understanding of the critical steps in this complex process will enable more effective clinical intervention to be developed to reduce the mortality exacted by this versatile pathogen.

Original languageEnglish
Pages (from-to)1057-1067
Number of pages11
JournalJournal of Medical Microbiology
Issue number12
Publication statusPublished - 1 Jan 2000


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