Palladium-catalyzed direct C-H functionalization of benzoquinone

Sarah E. Walker; James A. Jordan-Hore; David G. Johnson; Stuart A. MacGregor; Ai Lan Lee

doi:10.1002/anie.201408054

Palladium-catalyzed direct C-H functionalization of benzoquinone

Sarah E. Walker, James A. Jordan-Hore, David G. Johnson, Stuart A. MacGregor^*, Ai Lan Lee

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A direct Pd-catalyzed C-H functionalization of benzoquinone (BQ) can be controlled to give either mono- or disubstituted BQ, including the installation of two different groups in a one-pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cyclo-alkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.

Original language	English
Pages (from-to)	13876-13879
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	53
Issue number	50
DOIs	https://doi.org/10.1002/anie.201408054
Publication status	Published - 10 Oct 2014

Keywords

Benzoquinone
C-H functionalization
Palladium
Synthetic methods
Water

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title = "Palladium-catalyzed direct C-H functionalization of benzoquinone",

abstract = "A direct Pd-catalyzed C-H functionalization of benzoquinone (BQ) can be controlled to give either mono- or disubstituted BQ, including the installation of two different groups in a one-pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cyclo-alkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.",

keywords = "Benzoquinone, C-H functionalization, Palladium, Synthetic methods, Water",

author = "Walker, \{Sarah E.\} and Jordan-Hore, \{James A.\} and Johnson, \{David G.\} and MacGregor, \{Stuart A.\} and Lee, \{Ai Lan\}",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

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doi = "10.1002/anie.201408054",

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T1 - Palladium-catalyzed direct C-H functionalization of benzoquinone

AU - Walker, Sarah E.

AU - Jordan-Hore, James A.

AU - Johnson, David G.

AU - MacGregor, Stuart A.

AU - Lee, Ai Lan

PY - 2014/10/10

Y1 - 2014/10/10

N2 - A direct Pd-catalyzed C-H functionalization of benzoquinone (BQ) can be controlled to give either mono- or disubstituted BQ, including the installation of two different groups in a one-pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cyclo-alkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.

AB - A direct Pd-catalyzed C-H functionalization of benzoquinone (BQ) can be controlled to give either mono- or disubstituted BQ, including the installation of two different groups in a one-pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cyclo-alkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.

KW - Benzoquinone

KW - C-H functionalization

KW - Palladium

KW - Synthetic methods

KW - Water

UR - https://www.scopus.com/pages/publications/84919390782

U2 - 10.1002/anie.201408054

DO - 10.1002/anie.201408054

M3 - Article

AN - SCOPUS:84919390782

SN - 1433-7851

VL - 53

SP - 13876

EP - 13879

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 50

ER -

Palladium-catalyzed direct C-H functionalization of benzoquinone

Abstract

Keywords

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