Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

Edward J. Milton; Matthew L. Clarke

doi:10.1039/b921026a

Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

Research output: Contribution to journal › Article › peer-review

Abstract

The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl-2] pre-catalysts from sodium tetrachloropalladate in very high yield.

Original language	English
Pages (from-to)	381-383
Number of pages	3
Journal	Green Chemistry
Volume	12
Issue number	3
DOIs	https://doi.org/10.1039/b921026a
Publication status	Published - 2010

Keywords

CARBON BOND FORMATION
ARYL CHLORIDES
ORGANIC HALIDES
ALKYL-HALIDES
REAGENTS
COMPLEXES
ETHERS

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10.1039/b921026a

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abstract = "The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl-2] pre-catalysts from sodium tetrachloropalladate in very high yield.",

keywords = "CARBON BOND FORMATION, ARYL CHLORIDES, ORGANIC HALIDES, ALKYL-HALIDES, REAGENTS, COMPLEXES, ETHERS",

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year = "2010",

doi = "10.1039/b921026a",

language = "English",

volume = "12",

pages = "381--383",

journal = "Green Chemistry",

issn = "1463-9262",

publisher = "Royal Society of Chemistry",

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T1 - Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

AU - Milton, Edward J.

AU - Clarke, Matthew L.

PY - 2010

Y1 - 2010

N2 - The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl-2] pre-catalysts from sodium tetrachloropalladate in very high yield.

AB - The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl-2] pre-catalysts from sodium tetrachloropalladate in very high yield.

KW - CARBON BOND FORMATION

KW - ARYL CHLORIDES

KW - ORGANIC HALIDES

KW - ALKYL-HALIDES

KW - REAGENTS

KW - COMPLEXES

KW - ETHERS

UR - http://www.scopus.com/inward/record.url?scp=77949350993&partnerID=8YFLogxK

U2 - 10.1039/b921026a

DO - 10.1039/b921026a

M3 - Article

SN - 1463-9262

VL - 12

SP - 381

EP - 383

JO - Green Chemistry

JF - Green Chemistry

IS - 3

ER -

Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

Abstract

Keywords

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