Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

Edward J. Milton, Matthew L. Clarke

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl-2] pre-catalysts from sodium tetrachloropalladate in very high yield.

Original languageEnglish
Pages (from-to)381-383
Number of pages3
JournalGreen Chemistry
Volume12
Issue number3
DOIs
Publication statusPublished - 2010

Keywords

  • CARBON BOND FORMATION
  • ARYL CHLORIDES
  • ORGANIC HALIDES
  • ALKYL-HALIDES
  • REAGENTS
  • COMPLEXES
  • ETHERS

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