Abstract
The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl-2] pre-catalysts from sodium tetrachloropalladate in very high yield.
Original language | English |
---|---|
Pages (from-to) | 381-383 |
Number of pages | 3 |
Journal | Green Chemistry |
Volume | 12 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- CARBON BOND FORMATION
- ARYL CHLORIDES
- ORGANIC HALIDES
- ALKYL-HALIDES
- REAGENTS
- COMPLEXES
- ETHERS