Palladium catalysed elaboration of codeine and morphine

S. G. Davies; C. J. Goodwin; D. Pyatt; A. D. Smith

doi:10.1039/b102581n

Palladium catalysed elaboration of codeine and morphine

S. G. Davies^*, C. J. Goodwin, D. Pyatt, A. D. Smith

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bromocodeine and 6-O-tert-butyldimethylsilyl-3-trifluoromethylsulfonylmorphine allow a range of substituted analogues of codeine in the 1-position and morphine in the 3-position to be efficiently and selectively prepared.

Original language	English
Pages (from-to)	1413-1420
Number of pages	8
Journal	Journal of the Chemical Society. Perkin Transactions 1
Issue number	12
DOIs	https://doi.org/10.1039/b102581n
Publication status	Published - 1 Jan 2001

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title = "Palladium catalysed elaboration of codeine and morphine",

abstract = "Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bromocodeine and 6-O-tert-butyldimethylsilyl-3-trifluoromethylsulfonylmorphine allow a range of substituted analogues of codeine in the 1-position and morphine in the 3-position to be efficiently and selectively prepared.",

author = "Davies, {S. G.} and Goodwin, {C. J.} and D. Pyatt and Smith, {A. D.}",

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Palladium catalysed elaboration of codeine and morphine

Abstract

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