Palladium catalysed elaboration of codeine and morphine

S. G. Davies*, C. J. Goodwin, D. Pyatt, A. D. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bromocodeine and 6-O-tert-butyldimethylsilyl-3-trifluoromethylsulfonylmorphine allow a range of substituted analogues of codeine in the 1-position and morphine in the 3-position to be efficiently and selectively prepared.

Original languageEnglish
Pages (from-to)1413-1420
Number of pages8
JournalJournal of the Chemical Society. Perkin Transactions 1
Issue number12
Publication statusPublished - 1 Jan 2001


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