Oxidation of retinyl acetate and analogues by nitric oxide and nitrogen dioxide

Mohammad Afzal, John C. Walton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Nitric oxide did not react directly with retinyl acetate but, in the presence of an initiator, a series of nitroxide radicals was produced and observed by EPR spectroscopy. Product analyses showed that rapid oxidative degradation of retinyl acetate gave a series of carbonyl compounds. NO operating in concert with a self-derived initiator such as NO2 on unsaturated lipids could account for the cytotoxicity of this molecule.

Original languageEnglish
Pages (from-to)2329-2332
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number19
DOIs
Publication statusPublished - 8 Oct 1996

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