Oxidation of retinyl acetate and analogues by nitric oxide and nitrogen dioxide

Mohammad Afzal; John C. Walton

doi:10.1016/0960-894X(96)00422-2

Oxidation of retinyl acetate and analogues by nitric oxide and nitrogen dioxide

Mohammad Afzal, John C. Walton^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Nitric oxide did not react directly with retinyl acetate but, in the presence of an initiator, a series of nitroxide radicals was produced and observed by EPR spectroscopy. Product analyses showed that rapid oxidative degradation of retinyl acetate gave a series of carbonyl compounds. NO operating in concert with a self-derived initiator such as NO₂ on unsaturated lipids could account for the cytotoxicity of this molecule.

Original language	English
Pages (from-to)	2329-2332
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	19
DOIs	https://doi.org/10.1016/0960-894X(96)00422-2
Publication status	Published - 8 Oct 1996

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title = "Oxidation of retinyl acetate and analogues by nitric oxide and nitrogen dioxide",

abstract = "Nitric oxide did not react directly with retinyl acetate but, in the presence of an initiator, a series of nitroxide radicals was produced and observed by EPR spectroscopy. Product analyses showed that rapid oxidative degradation of retinyl acetate gave a series of carbonyl compounds. NO operating in concert with a self-derived initiator such as NO2 on unsaturated lipids could account for the cytotoxicity of this molecule.",

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year = "1996",

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AU - Afzal, Mohammad

AU - Walton, John C.

PY - 1996/10/8

Y1 - 1996/10/8

N2 - Nitric oxide did not react directly with retinyl acetate but, in the presence of an initiator, a series of nitroxide radicals was produced and observed by EPR spectroscopy. Product analyses showed that rapid oxidative degradation of retinyl acetate gave a series of carbonyl compounds. NO operating in concert with a self-derived initiator such as NO2 on unsaturated lipids could account for the cytotoxicity of this molecule.

AB - Nitric oxide did not react directly with retinyl acetate but, in the presence of an initiator, a series of nitroxide radicals was produced and observed by EPR spectroscopy. Product analyses showed that rapid oxidative degradation of retinyl acetate gave a series of carbonyl compounds. NO operating in concert with a self-derived initiator such as NO2 on unsaturated lipids could account for the cytotoxicity of this molecule.

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U2 - 10.1016/0960-894X(96)00422-2

DO - 10.1016/0960-894X(96)00422-2

M3 - Article

AN - SCOPUS:0030575616

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VL - 6

SP - 2329

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Oxidation of retinyl acetate and analogues by nitric oxide and nitrogen dioxide

Abstract

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