Ovarian function and fertility preservation for young people treated for cancer

Soline Caprioli, Tom Kelsey, W Hamish B Wallace

Research output: Chapter in Book/Report/Conference proceedingChapter


Further advances in the treatment of young people with cancer have led to improved survival, with 85.6% 5-year relative survival for ages 0–14 in the USA for the years 2010–2016 [18]. However, successful cancer treatment during childhood can cause infertility and premature ovarian insufficiency (POI) in some patients [20, 33]. The risk of developing POI is dependent on a number of factors, which include the nature of the underlying disease and the planned therapy. Both chemotherapy and radiotherapy have been shown to affect ovarian function either directly by depleting the primordial follicle pool or indirectly via effects on hormonal regulation of ovarian function.
Original languageEnglish
Title of host publicationFemale and male fertility preservation
EditorsMichael Grynberg, Pasquale Patrizio
Place of PublicationCham
ISBN (Electronic)9783030477677
ISBN (Print)9783030477660, 9783030477691
Publication statusPublished - 1 Jan 2022


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