Abstract
Further advances in the treatment of young people with cancer have led to improved survival, with 85.6% 5-year relative survival for ages 0–14 in the USA for the years 2010–2016 [18]. However, successful cancer treatment during childhood can cause infertility and premature ovarian insufficiency (POI) in some patients [20, 33]. The risk of developing POI is dependent on a number of factors, which include the nature of the underlying disease and the planned therapy. Both chemotherapy and radiotherapy have been shown to affect ovarian function either directly by depleting the primordial follicle pool or indirectly via effects on hormonal regulation of ovarian function.
| Original language | English |
|---|---|
| Title of host publication | Female and male fertility preservation |
| Editors | Michael Grynberg, Pasquale Patrizio |
| Place of Publication | Cham |
| Publisher | Springer |
| Pages | 35-45 |
| ISBN (Electronic) | 9783030477677 |
| ISBN (Print) | 9783030477660, 9783030477691 |
| DOIs | |
| Publication status | Published - 1 Jan 2022 |
Access to Document
- Caprioli_2021_OvarianFunction_Chapter_AAM
Copyright © Springer Nature Switzerland AG 2022. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1007/978-3-030-47767-7_3