Orthogonal N, N-deprotection strategies of β-amino esters

Steven D. Bull, Stephen G. Davies*, Peter M. Kelly, Massimo Gianotti, Andrew D. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


β-Amino esters derived from the stereoselective conjugate addition of homochiral lithium N-benzyl-N-α-methyl-4-methoxybenzylamide to α,β-unsaturated esters may be orthogonally mono-N-deprotected under either oxidative or acid-promoted reaction conditions. Further oxidative deprotection affords β-amino acids or β-lactams.

Original languageEnglish
Pages (from-to)3106-3111
Number of pages6
JournalJournal of the Chemical Society. Perkin Transactions 1
Issue number23
Publication statusPublished - 12 Nov 2001


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