Origins and properties of Mycobacterium tuberculosis isolates in London

J W Dale, G H Bothamley, F Drobniewski, S H Gillespie, T D McHugh, R Pitman

Research output: Contribution to journalArticlepeer-review

Abstract

Using similarities of IS61 10 banding patterns, isolates of Mycobacterium tuberculosis from a population-based study in London were assigned to 12 large groups termed 'superfamilies'(sfams). Analysis of patient data showed a marked geographical association in the distribution of these sfams. In particular, isolates from patients born in Europe were from different sfams than those born elsewhere, indicating that there had been relatively little transmission of tuberculosis in London from immigrant communities into the endogenous population. Multivariate analysis showed that certain sfams were significantly associated with pulmonary rather than extrapulmonary disease, or with sputum smear negativity, independently of country of birth or ethnicity, suggesting that the properties of the infecting organism play a role in the nature of the disease process.

Original languageEnglish
Pages (from-to)575-582
Number of pages8
JournalJournal of Medical Microbiology
Volume54
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • MOLECULAR EPIDEMIOLOGY
  • BEIJING GENOTYPE
  • BORN PERSONS
  • STRAINS
  • TRANSMISSION
  • PATHOGENESIS
  • MARKERS
  • FAMILY

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