Origin of excitatory drive to a spinal locomotor network.

A Roberts, Wenchang Li, SR Soffe, E Wolf

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

A long-standing hypotheses is that locomotion is turned on by descending excitatory synaptic drive. in young frog tadpoles, we show that prolonged swimming in response to a brief stimulus can be generated by a small region of caudal hindbrain and rostral spinal cord. Whole-cell patch recordings in this region identify hindbrain neurons that excite spinal neurons to drive swimming. Some of these hindbrain reticulospinal neurons excite each other. We consider how feedback excitation within the hindbrain may provide a mechanism to drive spinal locomotor networks. (c) 2007 Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)22-28 (review)
Number of pages7
JournalBrain Research Reviews
Volume57
DOIs
Publication statusPublished - Jan 2008

Keywords

  • feedback
  • locomotion
  • reticulospinal
  • rhythm generation
  • synapses
  • xenopus
  • XENOPUS EMBRYOS
  • INHIBITORY INTERNEURONS
  • RETICULOSPINAL NEURONS
  • PLATEAU POTENTIALS
  • BRAIN-STEM
  • CORD
  • STIMULATION
  • PROJECTIONS
  • SYSTEM
  • REGION

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