Organocatalytic Synthesis of Fused Bicyclic 2,3-Dihydro-1,3,4-oxadiazoles through an Intramolecular Cascade Cyclization

Alison J. Fugard, Bethany K. Thompson, Alexandra M. Z. Slawin, James E. Taylor*, Andrew D. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Hydrazone-carboxylic acids undergo intramolecular cyclization in the presence of pivaloyl chloride, iPr(2)NEt, and catalytic DABCO to form a range of substituted fused tricyclic 2,3-dihydro-1,3,4-oxadiazoles in high yields.

Original languageEnglish
Pages (from-to)5824-5827
Number of pages4
JournalOrganic Letters
Volume17
Issue number23
DOIs
Publication statusPublished - 4 Dec 2015

Keywords

  • ONE-POT SYNTHESIS
  • ASYMMETRIC-SYNTHESIS
  • BIOLOGICAL EVALUATION
  • BETA-LACTAMS
  • ACID-DERIVATIVES
  • AGENTS
  • DESIGN
  • COMBRETASTATIN-A4
  • LACTONIZATION
  • PYRIDINES

Fingerprint

Dive into the research topics of 'Organocatalytic Synthesis of Fused Bicyclic 2,3-Dihydro-1,3,4-oxadiazoles through an Intramolecular Cascade Cyclization'. Together they form a unique fingerprint.

Cite this