Abstract
This tutorial review highlights the organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium/azolium enolates. The generation and synthetic utility of these powerful intermediates is highlighted through their application in various methodologies including aldol-lactonisations, Michael-lactonisations/lactamisations and [2,3]-rearrangements.
| Original language | English |
|---|---|
| Pages (from-to) | 6214-6226 |
| Number of pages | 13 |
| Journal | Chemical Society Reviews |
| Volume | 43 |
| Issue number | 17 |
| Early online date | 28 May 2014 |
| DOIs | |
| Publication status | Published - 7 Sept 2014 |
Keywords
- Bicyclic-Beta-Lactones
- Catalyzed Aldol-Lactonization
- Promoted Bis-Cyclizations
- One-Pot Synthesis
- Asymmetric-Synthesis
- Dyotropic Rearrangements
- Ncal Reactions
- Keto Acids
- Activation
- Derivatives