Optical coherence tomography for the diagnosis, monitoring and guiding of treatment for neovascular age-related macular degeneration: a systematic review and economic evaluation

G. Mowatt, R. Hernández, M. Castillo, N. Lois, A. Elders, C. Fraser, O. Aremu, W. Amoaku, J. Burr, A. Lotery, C. Ramsay, A. Azuara-Blanco

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Abstract

Results: In pooled estimates of diagnostic studies (all TD-OCT), sensitivity and specificity [95% confidence interval (CI)] was 88% (46% to 98%) and 78% (64% to 88%) respectively. For monitoring, the pooled sensitivity and specificity (95% CI) was 85% (72% to 93%) and 48% (30% to 67%) respectively. The FFA for diagnosis and nurse-technician-led monitoring strategy had the lowest cost (£39,769; QALYs 10.473) and dominated all others except FFA for diagnosis and ophthalmologist-led monitoring (£44,649; QALYs 10.575; incremental cost-effectiveness ratio £47,768). The least costly strategy had a 46.4% probability of being cost-effective at £30,000 willingness-to-pay threshold.
Original languageEnglish
Pages (from-to)1-253
Number of pages253
JournalHealth Technology Assessment
Volume18
Issue number69
DOIs
Publication statusPublished - Nov 2014

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