Optical analysis of homocysteine metabolites using vibrational spectroscopy

Mingzhou Chen, Lisa Strother, Gayle Helane Doherty, Kishan Dholakia

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Abstract

Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for
detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.
Original languageEnglish
Pages (from-to)1958-1966
Number of pages9
JournalOSA Continuum
Volume3
Issue number7
Early online date7 Jul 2020
DOIs
Publication statusPublished - 15 Jul 2020

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