Optical analysis of homocysteine metabolites using vibrational spectroscopy

Mingzhou Chen; Lisa Strother; Gayle Helane Doherty; Kishan Dholakia

doi:10.1364/OSAC.397780

Optical analysis of homocysteine metabolites using vibrational spectroscopy

Mingzhou Chen, Lisa Strother, Gayle Helane Doherty, Kishan Dholakia

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Abstract

Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches for
detection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.

Original language	English
Pages (from-to)	1958-1966
Number of pages	9
Journal	OSA Continuum
Volume	3
Issue number	7
Early online date	7 Jul 2020
DOIs	https://doi.org/10.1364/OSAC.397780
Publication status	Published - 15 Jul 2020

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10.1364/OSAC.397780Licence: CC BY

Chen-2020-Optical-analysis-of-OSAC-3-7-1958-CC
Copyright © 2020 the Author(s). Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
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Resonant and shaped photonics for under: Resonant and shaped photonics for understanding the physical and biomedical world
Dholakia, K. (PI) & Gather, M. C. (CoI)
1/08/17 → 31/07/22
Project: Standard
EU FP7 FAMOS: Functional Anatomical Molecular Optical Screening
Dholakia, K. (PI)
European Commission
1/10/12 → 31/03/17
Project: Standard

Cite this

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title = "Optical analysis of homocysteine metabolites using vibrational spectroscopy",

abstract = "Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches fordetection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.",

author = "Mingzhou Chen and Lisa Strother and Doherty, {Gayle Helane} and Kishan Dholakia",

note = "Funding: Funding: European Union FAMOS project (FP7-ICT-317744); Engineering and Physical Sciences Research Council (EP/P030017/1); RS MacDonald Charitable Trust.",

year = "2020",

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doi = "10.1364/OSAC.397780",

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T1 - Optical analysis of homocysteine metabolites using vibrational spectroscopy

AU - Chen, Mingzhou

AU - Strother, Lisa

AU - Doherty, Gayle Helane

AU - Dholakia, Kishan

N1 - Funding: Funding: European Union FAMOS project (FP7-ICT-317744); Engineering and Physical Sciences Research Council (EP/P030017/1); RS MacDonald Charitable Trust.

PY - 2020/7/15

Y1 - 2020/7/15

N2 - Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches fordetection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.

AB - Homocysteine (HCy) is a sulphur-containing amino acid that correlates with several maladaptive health conditions, including an enhanced risk of cardiovascular and neurodegenerative diseases. Detection of HCy and its potentially pathogenic metabolites are studied here for the first time, to the first of our knowledge, using Raman spectroscopy. This study shows that different HCy metabolites have distinct Raman spectra and that the limits of detection reach the sub-mM level for these compounds. This investigation paves the way for photonics–based approaches fordetection of HCy–related fluids as predictive biomarkers of disease in blood, which would assist in early intervention for improved clinical outcomes.

U2 - 10.1364/OSAC.397780

DO - 10.1364/OSAC.397780

M3 - Article

SN - 2578-7519

VL - 3

SP - 1958

EP - 1966

JO - OSA Continuum

JF - OSA Continuum

IS - 7

ER -

Optical analysis of homocysteine metabolites using vibrational spectroscopy

Abstract

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Projects

Resonant and shaped photonics for under: Resonant and shaped photonics for understanding the physical and biomedical world

EU FP7 FAMOS: Functional Anatomical Molecular Optical Screening

Cite this