One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase

Michael J. Corr, Duncan R. M. Smith, Rebecca J. M. Goss

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
2 Downloads (Pure)

Abstract

We report, for the first time, the use of tryptophan synthase in the generation of L- dihalotryptophans and L-alkynyltryptophans. These previously unpublished compounds will be useful tools in the generation of probes for chemical biology, in biosynthetic diversification and as convenient building blocks for synthesis.
Original languageEnglish
Pages (from-to)7306-7310
Number of pages5
JournalTetrahedron
Volume72
Issue number46
Early online date9 Feb 2016
DOIs
Publication statusPublished - 17 Nov 2016

Keywords

  • Biotransformation
  • Dihalotryptophan
  • Alkynyltryptophan
  • Tryptophan synthase

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