Abstract
Partial differential equations describing the dynamics of cell population densities from a fluid mechanical perspective can model the growth of avascular tumours. In this framework, we consider a system of equations that describes the interaction between a population of dividing cells and a population of non-dividing cells. The two cell populations are characterised by different mobilities. We present the results of numerical simulations displaying two-dimensional spherical waves with sharp interfaces between dividing and non-dividing cells. Furthermore, we numerically observe how different ratios between the mobilities change the morphology of the interfaces, and lead to the emergence of finger-like patterns of invasion above a threshold. Motivated by these simulations, we study the existence of one-dimensional travelling wave solutions.
| Original language | English |
|---|---|
| Pages (from-to) | 299-311 |
| Journal | Kinetic and Related Models |
| Volume | 10 |
| Issue number | 1 |
| Early online date | 1 Nov 2016 |
| DOIs | |
| Publication status | Published - Mar 2017 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cell populations
- Tissue growth
- Cancer invasion
- Interfaces
- Travelling waves
- Pattern formation
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