Nucleosome dynamics

C Stockdale, M Bruno, H Ferreira, E Garcia-Wilson, N Wiechens, M Engeholm, A Flaus, T Owen-Hughes*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

Original languageEnglish
Title of host publicationTRANSCRIPTION
EditorsSGE Roberts, ROJ Weinzierl, RJ White
Place of PublicationLONDON
PublisherPortland Press Ltd.
Pages109-119
Number of pages11
ISBN (Print)1-85578-163-8
Publication statusPublished - 2006
Event73th Biochemical-Society Symposium - London, United Kingdom
Duration: 1 Apr 2005 → …

Publication series

NameBIOCHEMICAL SOCIETY SYMPOSIUM
PublisherPORTLAND PRESS LTD
ISSN (Print)0067-8694

Conference

Conference73th Biochemical-Society Symposium
Country/TerritoryUnited Kingdom
Period1/04/05 → …

Keywords

  • H3 LYSINE-27 METHYLATION
  • INACTIVE X-CHROMOSOME
  • DNA TARGET SITES
  • CHROMATIN FIBER
  • HISTONE OCTAMER
  • IN-VITRO
  • CORE PARTICLES
  • BINDING-SITE
  • FACILITATED BINDING
  • POSITIVE ROLE

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