Nuclear organization of pre-mRNA splicing factors.

Judith Elizabeth Sleeman; AI Lamond

doi:10.1016/5095-0674(99)80052-0

Nuclear organization of pre-mRNA splicing factors.

Research output: Contribution to journal › Article › peer-review

Abstract

The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.

Original language	English
Pages (from-to)	372-7
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/5095-0674(99)80052-0
Publication status	Published - Jun 1999

Keywords

SPINAL MUSCULAR-ATROPHY
DISEASE GENE-PRODUCT
COILED BODIES
PROTEIN PHOSPHATASE-1
MAMMALIAN-CELLS
SR PROTEINS
INTRANUCLEAR DISTRIBUTION
SPLICEOSOMAL SNRNPS
IN-VIVO
RNA

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title = "Nuclear organization of pre-mRNA splicing factors.",

abstract = "The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.",

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author = "Sleeman, {Judith Elizabeth} and AI Lamond",

year = "1999",

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T1 - Nuclear organization of pre-mRNA splicing factors.

AU - Sleeman, Judith Elizabeth

AU - Lamond, AI

PY - 1999/6

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N2 - The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.

AB - The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.

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KW - DISEASE GENE-PRODUCT

KW - COILED BODIES

KW - PROTEIN PHOSPHATASE-1

KW - MAMMALIAN-CELLS

KW - SR PROTEINS

KW - INTRANUCLEAR DISTRIBUTION

KW - SPLICEOSOMAL SNRNPS

KW - IN-VIVO

KW - RNA

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EP - 377

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 3

ER -

Nuclear organization of pre-mRNA splicing factors.

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Keywords

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