Nuclear organization of pre-mRNA splicing factors.

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79 Citations (Scopus)

Abstract

The splicing of mRNA precursors (pre-mRNA) in the nucleus is catalyzed by a complex machinery termed the spliceosome. In order to understand how it functions in vivo, it is essential to complement biochemical analyses with a detailed study of how spliceosome components are organized within the nucleus.

Original languageEnglish
Pages (from-to)372-7
Number of pages6
JournalCurrent Opinion in Cell Biology
Volume11
Issue number3
DOIs
Publication statusPublished - Jun 1999

Keywords

  • SPINAL MUSCULAR-ATROPHY
  • DISEASE GENE-PRODUCT
  • COILED BODIES
  • PROTEIN PHOSPHATASE-1
  • MAMMALIAN-CELLS
  • SR PROTEINS
  • INTRANUCLEAR DISTRIBUTION
  • SPLICEOSOMAL SNRNPS
  • IN-VIVO
  • RNA

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