Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene

Xiaoliang Ba; Ewan M Harrison; Giles F Edwards; Matthew T G Holden; Anders Rhod Larsen; Andreas Petersen; Robert L Skov; Sharon J Peacock; Julian Parkhill; Gavin K Paterson; Mark A Holmes

doi:10.1093/jac/dkt418

Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene

Xiaoliang Ba, Ewan M Harrison, Giles F Edwards, Matthew T G Holden, Anders Rhod Larsen, Andreas Petersen, Robert L Skov, Sharon J Peacock, Julian Parkhill, Gavin K Paterson, Mark A Holmes

Research output: Contribution to journal › Article › peer-review

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is an important global health problem. MRSA resistance to β-lactam antibiotics is mediated by the mecA or mecC genes, which encode an alternative penicillin-binding protein (PBP) 2a that has a low affinity to β-lactam antibiotics. Detection of mec genes or PBP2a is regarded as the gold standard for the diagnosis of MRSA. We identified four MRSA isolates that lacked mecA or mecC genes, but were still phenotypically resistant to pencillinase-resistant β-lactam antibiotics.

Original language	English
Pages (from-to)	594-7
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	69
Issue number	3
Early online date	11 Nov 2013
DOIs	https://doi.org/10.1093/jac/dkt418
Publication status	Published - Mar 2014

Keywords

β-lactams
MRSA
mecA
mecC

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10.1093/jac/dkt418

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Ba, X., Harrison, E. M., Edwards, G. F., Holden, M. T. G., Larsen, A. R., Petersen, A., Skov, R. L., Peacock, S. J., Parkhill, J., Paterson, G. K., & Holmes, M. A. (2014). Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene. Journal of Antimicrobial Chemotherapy, 69(3), 594-7. https://doi.org/10.1093/jac/dkt418

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title = "Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) is an important global health problem. MRSA resistance to β-lactam antibiotics is mediated by the mecA or mecC genes, which encode an alternative penicillin-binding protein (PBP) 2a that has a low affinity to β-lactam antibiotics. Detection of mec genes or PBP2a is regarded as the gold standard for the diagnosis of MRSA. We identified four MRSA isolates that lacked mecA or mecC genes, but were still phenotypically resistant to pencillinase-resistant β-lactam antibiotics.",

keywords = "β-lactams, MRSA, mecA, mecC",

author = "Xiaoliang Ba and Harrison, {Ewan M} and Edwards, {Giles F} and Holden, {Matthew T G} and Larsen, {Anders Rhod} and Andreas Petersen and Skov, {Robert L} and Peacock, {Sharon J} and Julian Parkhill and Paterson, {Gavin K} and Holmes, {Mark A}",

year = "2014",

month = mar,

doi = "10.1093/jac/dkt418",

language = "English",

volume = "69",

pages = "594--7",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

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Ba, X, Harrison, EM, Edwards, GF, Holden, MTG, Larsen, AR, Petersen, A, Skov, RL, Peacock, SJ, Parkhill, J, Paterson, GK & Holmes, MA 2014, 'Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene', Journal of Antimicrobial Chemotherapy, vol. 69, no. 3, pp. 594-7. https://doi.org/10.1093/jac/dkt418

Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene. / Ba, Xiaoliang; Harrison, Ewan M; Edwards, Giles F et al.
In: Journal of Antimicrobial Chemotherapy, Vol. 69, No. 3, 03.2014, p. 594-7.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene

AU - Ba, Xiaoliang

AU - Harrison, Ewan M

AU - Edwards, Giles F

AU - Holden, Matthew T G

AU - Larsen, Anders Rhod

AU - Petersen, Andreas

AU - Skov, Robert L

AU - Peacock, Sharon J

AU - Parkhill, Julian

AU - Paterson, Gavin K

AU - Holmes, Mark A

PY - 2014/3

Y1 - 2014/3

N2 - Methicillin-resistant Staphylococcus aureus (MRSA) is an important global health problem. MRSA resistance to β-lactam antibiotics is mediated by the mecA or mecC genes, which encode an alternative penicillin-binding protein (PBP) 2a that has a low affinity to β-lactam antibiotics. Detection of mec genes or PBP2a is regarded as the gold standard for the diagnosis of MRSA. We identified four MRSA isolates that lacked mecA or mecC genes, but were still phenotypically resistant to pencillinase-resistant β-lactam antibiotics.

AB - Methicillin-resistant Staphylococcus aureus (MRSA) is an important global health problem. MRSA resistance to β-lactam antibiotics is mediated by the mecA or mecC genes, which encode an alternative penicillin-binding protein (PBP) 2a that has a low affinity to β-lactam antibiotics. Detection of mec genes or PBP2a is regarded as the gold standard for the diagnosis of MRSA. We identified four MRSA isolates that lacked mecA or mecC genes, but were still phenotypically resistant to pencillinase-resistant β-lactam antibiotics.

KW - β-lactams

KW - MRSA

KW - mecA

KW - mecC

U2 - 10.1093/jac/dkt418

DO - 10.1093/jac/dkt418

M3 - Article

C2 - 24216768

SN - 0305-7453

VL - 69

SP - 594

EP - 597

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

IS - 3

ER -

Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene

Abstract

Keywords

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