Nonrandom association of IS6110 and Mycobacterium-tuberculosis: Implications for molecular epidemiological studies

T. D. McHugh, S. H. Gillespie*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

IS6110 restriction fragment length polymorphism typing is now established as the primary typing method for Mycobacterium tuberculosis. It has been assumed that the position of hands is ramdom. Thus, the discrimination of the technique increases in proportion to the copy number. Two collections of M. tuberculosis were investigated to test this hypothesis. We identified 33 positions in isolates from a Tanzanian collection and 25 positions in-isolates from a London, United Kingdom, collection where bands were significantly more likely to be present than would be expected by chance. These data suggest that band position is not random, and this possibility may have an impact on the interpretation of molecular epidemiological studies of M. tuberculosis.

Original languageEnglish
Pages (from-to)1410-1413
Number of pages4
JournalJournal of Clinical Microbiology
Volume36
Issue number5
Publication statusPublished - 18 May 1998

Fingerprint

Dive into the research topics of 'Nonrandom association of IS6110 and Mycobacterium-tuberculosis: Implications for molecular epidemiological studies'. Together they form a unique fingerprint.

Cite this