No association between TPH2 gene polymorphisms and ADHD in a UK sample

K Sheehan; Z Hawi; M Gill; Lindsey Kent

doi:10.1016/j.neulet.2006.10.043

No association between TPH2 gene polymorphisms and ADHD in a UK sample

K Sheehan, Z Hawi, M Gill, Lindsey Kent

School of Medicine

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Recent molecular studies reported significant association between markers mapped to TPH2 and psychiatric conditions including ADHD. We have examined four single nucleotide polymorphisms (SNPs) two of which (rs1843809, rs1386493) were reported to associate with ADHD in an Irish ADHD sample. Transmission disequilibrium analysis revealed no significant association between any of these markers and ADHD. Dividing by the sex of the transmitting parent has also failed to replicate the previously reported paternal over-transmission of the associated alleles to ADHD probands. A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	105-107
Number of pages	3
Journal	Neuroscience Letters
Volume	412
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2006.10.043
Publication status	Published - 29 Jan 2007

Keywords

Attention Deficit Hyperactivity Disorder (ADHD)
Tryptophan Hydroxylase 2 (TPH2)
transmission disequilibrium test (TDT)
serotonergic system
genetic association
DEFICIT HYPERACTIVITY DISORDER
TRYPTOPHAN-HYDROXYLASE ISOFORM
ATTENTION-DEFICIT
MAJOR DEPRESSION
SEROTONIN

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10.1016/j.neulet.2006.10.043

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title = "No association between TPH2 gene polymorphisms and ADHD in a UK sample",

abstract = "Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Recent molecular studies reported significant association between markers mapped to TPH2 and psychiatric conditions including ADHD. We have examined four single nucleotide polymorphisms (SNPs) two of which (rs1843809, rs1386493) were reported to associate with ADHD in an Irish ADHD sample. Transmission disequilibrium analysis revealed no significant association between any of these markers and ADHD. Dividing by the sex of the transmitting parent has also failed to replicate the previously reported paternal over-transmission of the associated alleles to ADHD probands. A larger sample size will be required to clarify if TPH2 alleles are or are not associated with ADHD. (c) 2006 Elsevier Ireland Ltd. All rights reserved.",

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AU - Hawi, Z

AU - Gill, M

AU - Kent, Lindsey

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KW - Attention Deficit Hyperactivity Disorder (ADHD)

KW - Tryptophan Hydroxylase 2 (TPH2)

KW - transmission disequilibrium test (TDT)

KW - serotonergic system

KW - genetic association

KW - DEFICIT HYPERACTIVITY DISORDER

KW - TRYPTOPHAN-HYDROXYLASE ISOFORM

KW - ATTENTION-DEFICIT

KW - MAJOR DEPRESSION

KW - SEROTONIN

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VL - 412

SP - 105

EP - 107

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2

ER -

No association between TPH2 gene polymorphisms and ADHD in a UK sample

Abstract

Keywords

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