NMR and conformational studies of the antimalarial drug arte-ether

A R Butler, L Conforti, P Hulme, L M Renton, T J Rutherford

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12 Citations (Scopus)

Abstract

The H-1 and C-13 NMR spectra of the antimalarial drug arte-ether (a derivative of qinghaosu) have been obtained and stereospecific assignments made using standard one- and two-dimensional techniques. Proton homonuclear spin-coupling constants were quantified from J-resolved and E.COSY experiments and confirmed that the solution conformation of arte-ether is similar to that of the reported crystal structure of artmether. A conformational model was generated using AM1 semi-empirical energy calculations, and was consistent with both the measured spin-coupling constants and experimental NOE data.

Original languageEnglish
Pages (from-to)2089-2092
Number of pages4
JournalJournal of Chemical Society, Perkin Transactions 2
Issue number10
DOIs
Publication statusPublished - Oct 1999

Keywords

  • QINGHAOSU ARTEMISININ
  • ASSIGNMENTS
  • DERIVATIVES
  • ARTEMETHER
  • ARTEETHER
  • ANNUA
  • ACID

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