[(NHC)AuI]-Catalyzed Acid-Free Alkyne Hydration at Part-per-Million Catalyst Loadings

Nicolas Marion; Ruben S. Ramon; Steven Patrick Nolan

doi:10.1021/ja809403e

[(NHC)Au^I]-Catalyzed Acid-Free Alkyne Hydration at Part-per-Million Catalyst Loadings

Nicolas Marion, Ruben S. Ramon, Steven Patrick Nolan

Research output: Contribution to journal › Article › peer-review

421 Citations (Scopus)

Abstract

A highly efficient [(NHC)Au-1]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of atkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50-100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing any combination of alkyl and aryl substituents (alkyl/H, aryl/H, alkyl/alkyl, alkyl/aryl, and aryl/aryl) were found suitable substrates in the present catalytic system.

Original language	English
Pages (from-to)	448-449
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	131
Issue number	2
DOIs	https://doi.org/10.1021/ja809403e
Publication status	Published - 21 Jan 2009

Keywords

HIGHLY EFFICIENT CATALYSTS
HETEROCYCLIC CARBENES
GOLD
COMPLEXES
GOLD(III)
KETONES

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10.1021/ja809403e

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title = "[(NHC)AuI]-Catalyzed Acid-Free Alkyne Hydration at Part-per-Million Catalyst Loadings",

abstract = "A highly efficient [(NHC)Au-1]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of atkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50-100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing any combination of alkyl and aryl substituents (alkyl/H, aryl/H, alkyl/alkyl, alkyl/aryl, and aryl/aryl) were found suitable substrates in the present catalytic system.",

keywords = "HIGHLY EFFICIENT CATALYSTS, HETEROCYCLIC CARBENES, GOLD, COMPLEXES, GOLD(III), KETONES",

author = "Nicolas Marion and Ramon, {Ruben S.} and Nolan, {Steven Patrick}",

year = "2009",

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doi = "10.1021/ja809403e",

language = "English",

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T1 - [(NHC)AuI]-Catalyzed Acid-Free Alkyne Hydration at Part-per-Million Catalyst Loadings

AU - Marion, Nicolas

AU - Ramon, Ruben S.

AU - Nolan, Steven Patrick

PY - 2009/1/21

Y1 - 2009/1/21

N2 - A highly efficient [(NHC)Au-1]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of atkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50-100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing any combination of alkyl and aryl substituents (alkyl/H, aryl/H, alkyl/alkyl, alkyl/aryl, and aryl/aryl) were found suitable substrates in the present catalytic system.

AB - A highly efficient [(NHC)Au-1]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of atkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50-100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing any combination of alkyl and aryl substituents (alkyl/H, aryl/H, alkyl/alkyl, alkyl/aryl, and aryl/aryl) were found suitable substrates in the present catalytic system.

KW - HIGHLY EFFICIENT CATALYSTS

KW - HETEROCYCLIC CARBENES

KW - GOLD

KW - COMPLEXES

KW - GOLD(III)

KW - KETONES

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U2 - 10.1021/ja809403e

DO - 10.1021/ja809403e

M3 - Article

SN - 0002-7863

VL - 131

SP - 448

EP - 449

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 2

ER -

[(NHC)Au^I]-Catalyzed Acid-Free Alkyne Hydration at Part-per-Million Catalyst Loadings

Abstract

Keywords

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