[(NHC)AuI]-Catalyzed Acid-Free Alkyne Hydration at Part-per-Million Catalyst Loadings

Nicolas Marion, Ruben S. Ramon, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

389 Citations (Scopus)

Abstract

A highly efficient [(NHC)Au-1]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of atkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50-100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing any combination of alkyl and aryl substituents (alkyl/H, aryl/H, alkyl/alkyl, alkyl/aryl, and aryl/aryl) were found suitable substrates in the present catalytic system.

Original languageEnglish
Pages (from-to)448-449
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number2
DOIs
Publication statusPublished - 21 Jan 2009

Keywords

  • HIGHLY EFFICIENT CATALYSTS
  • HETEROCYCLIC CARBENES
  • GOLD
  • COMPLEXES
  • GOLD(III)
  • KETONES

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