New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

C. Louise Campbell; Kenneth Wood; C. Tom A Brown; Harry Moseley

doi:10.1117/12.2212240

New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

C. Louise Campbell, Kenneth Wood, C. Tom A Brown, Harry Moseley

School of Physics and Astronomy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

Original language	English
Title of host publication	Photonic Therapeutics and Diagnostics XII
Editors	Bernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J F Wong, Justus F Ilgner, Guillermo J Tearney, Kenton W Gregory, Laura Marcu, Melissa C Skala, Paul J Campagnola, Andreas Mandelis, Michael D Morris
Publisher	SPIE
ISBN (Print)	9781628419245
DOIs	https://doi.org/10.1117/12.2212240
Publication status	Published - 29 Feb 2016
Event	Photonic Therapeutics and Diagnostics XII - San Francisco, United States Duration: 13 Feb 2016 → 14 Feb 2016

Publication series

Name	Proceedings of SPIE
Volume	9689
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Photonic Therapeutics and Diagnostics XII
Country/Territory	United States
City	San Francisco
Period	13/02/16 → 14/02/16

Keywords

Daylight PDT
Fractal model
Monte Carlo radiation transfer
Non-homogeneous tumour model
Photodynamic therapy
Skin optics

Access to Document

10.1117/12.2212240

Campbell_2016_NewInsights_ProcSPIE_96890Q
© 2016, SPIE. This work is made available online in accordance with the publisher’s policies. This is the final published version of the work, which was originally published at proceedings.spiedigitallibrary.org / https://dx.doi.org/10.1117/12.2212240
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Campbell, C. L., Wood, K., Brown, C. T. A., & Moseley, H. (2016). New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. In B. Choi, N. Kollias, H. Zeng, H. Wook Kang, B. J. F. Wong, J. F. Ilgner, G. J. Tearney, K. W. Gregory, L. Marcu, M. C. Skala, P. J. Campagnola, A. Mandelis, & M. D. Morris (Eds.), Photonic Therapeutics and Diagnostics XII Article 96890Q (Proceedings of SPIE; Vol. 9689). SPIE. https://doi.org/10.1117/12.2212240

Campbell, C. Louise ; Wood, Kenneth ; Brown, C. Tom A et al. / New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. Photonic Therapeutics and Diagnostics XII. editor / Bernard Choi ; Nikiforos Kollias ; Haishan Zeng ; Hyun Wook Kang ; Brian J F Wong ; Justus F Ilgner ; Guillermo J Tearney ; Kenton W Gregory ; Laura Marcu ; Melissa C Skala ; Paul J Campagnola ; Andreas Mandelis ; Michael D Morris. SPIE, 2016. (Proceedings of SPIE).

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title = "New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling",

abstract = "Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.",

keywords = "Daylight PDT, Fractal model, Monte Carlo radiation transfer, Non-homogeneous tumour model, Photodynamic therapy, Skin optics",

author = "Campbell, {C. Louise} and Kenneth Wood and Brown, {C. Tom A} and Harry Moseley",

note = "We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell (EP/K503162/1), the Alfred Stewart Trust as well as the BMLA Education Award.; Photonic Therapeutics and Diagnostics XII ; Conference date: 13-02-2016 Through 14-02-2016",

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editor = "Bernard Choi and Nikiforos Kollias and Haishan Zeng and {Wook Kang}, Hyun and Wong, {Brian J F} and Ilgner, {Justus F} and Tearney, {Guillermo J} and Gregory, {Kenton W} and Laura Marcu and Skala, {Melissa C} and Campagnola, {Paul J} and Andreas Mandelis and Morris, {Michael D}",

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Campbell, CL, Wood, K , Brown, CTA & Moseley, H 2016, New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. in B Choi, N Kollias, H Zeng, H Wook Kang, BJF Wong, JF Ilgner, GJ Tearney, KW Gregory, L Marcu, MC Skala, PJ Campagnola, A Mandelis & MD Morris (eds), Photonic Therapeutics and Diagnostics XII., 96890Q, Proceedings of SPIE, vol. 9689, SPIE, Photonic Therapeutics and Diagnostics XII, San Francisco, United States, 13/02/16. https://doi.org/10.1117/12.2212240

New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. / Campbell, C. Louise; Wood, Kenneth ; Brown, C. Tom A et al.
Photonic Therapeutics and Diagnostics XII. ed. / Bernard Choi; Nikiforos Kollias; Haishan Zeng; Hyun Wook Kang; Brian J F Wong; Justus F Ilgner; Guillermo J Tearney; Kenton W Gregory; Laura Marcu; Melissa C Skala; Paul J Campagnola; Andreas Mandelis; Michael D Morris. SPIE, 2016. 96890Q (Proceedings of SPIE; Vol. 9689).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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T1 - New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

AU - Campbell, C. Louise

AU - Wood, Kenneth

AU - Brown, C. Tom A

AU - Moseley, Harry

N1 - We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell (EP/K503162/1), the Alfred Stewart Trust as well as the BMLA Education Award.

PY - 2016/2/29

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N2 - Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

AB - Photodynamic therapy (PDT) has been theoretically investigated using a Monte Carlo radiation transfer (MCRT) model. By including complex three dimensional (3D) tumour models a more appropriate representation of the treatment was achieved. The 3D clustered tumour model was compared to a smooth model, resulting in a significantly deeper penetration associated with the clustered model. The results from the work presented here indicates that light might penetrate deeper than suggested by 2D or simple layered models.

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KW - Fractal model

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KW - Non-homogeneous tumour model

KW - Photodynamic therapy

KW - Skin optics

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A2 - Wong, Brian J F

A2 - Ilgner, Justus F

A2 - Tearney, Guillermo J

A2 - Gregory, Kenton W

A2 - Marcu, Laura

A2 - Skala, Melissa C

A2 - Campagnola, Paul J

A2 - Mandelis, Andreas

A2 - Morris, Michael D

PB - SPIE

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Campbell CL, Wood K , Brown CTA, Moseley H. New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling. In Choi B, Kollias N, Zeng H, Wook Kang H, Wong BJF, Ilgner JF, Tearney GJ, Gregory KW, Marcu L, Skala MC, Campagnola PJ, Mandelis A, Morris MD, editors, Photonic Therapeutics and Diagnostics XII. SPIE. 2016. 96890Q. (Proceedings of SPIE). doi: 10.1117/12.2212240

New insights into photodynamic therapy treatment through the use of 3D Monte Carlo radiation transfer modelling

Abstract

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Keywords

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