Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

C E Oldreive; J Z Harvey; Gayle Helane Doherty

doi:10.1016/j.neulet.2008.04.045

Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

C E Oldreive, J Z Harvey, Gayle Helane Doherty

School of Psychology and Neuroscience

Research output: Contribution to journal › Article › peer-review

Abstract

As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	17-21
Number of pages	5
Journal	Neuroscience Letters
Volume	438
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2008.04.045
Publication status	Published - 13 Jun 2008

Keywords

cell death
cerebellum
leptin
granule
neurite
Purkinje
CELL-DEATH
HIPPOCAMPAL-NEURONS
EXPRESSION
BRAIN
HOMOCYSTEINE
APOPTOSIS
PROTECTS
RECEPTOR
MICE

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neulet.2008.04.045

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title = "Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro",

abstract = "As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.",

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AU - Oldreive, C E

AU - Harvey, J Z

AU - Doherty, Gayle Helane

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Y1 - 2008/6/13

N2 - As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

AB - As recent evidence has revealed a pro-survival role for the anti-obesity hormone leptin in the nervous system, we investigated the generality of this finding on cerebellar Purkinje and granule neurons in vitro. We found that whilst leptin promoted cerebellar Purkinje neuron survival, it had no affect on cerebellar granule cells. In addition, we discovered that leptin promoted both the outgrowth of neurites from cerebellar Purkinje neurons and increased the complexity of the neurite arbor. Thus, leptin has different effects on two neighbouring populations of neurons within the cerebellum implying specificity of its actions in the central nervous system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

KW - cell death

KW - cerebellum

KW - leptin

KW - granule

KW - neurite

KW - Purkinje

KW - CELL-DEATH

KW - HIPPOCAMPAL-NEURONS

KW - EXPRESSION

KW - BRAIN

KW - HOMOCYSTEINE

KW - APOPTOSIS

KW - PROTECTS

KW - RECEPTOR

KW - MICE

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EP - 21

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Neurotrophic effects of leptin on cerebellar Purkinje but not granule neurons in vitro

Abstract

Keywords

UN SDGs

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