Neuroanatomy of the grey seal brain: bringing pinnipeds into the neurobiological study of vocal learning

Nienke Hoeksema*, Laura Verga, Janine Mengede, Corné van Roessel, Stella Villanueva, Anna Salazar-Casals, Ana Rubio-Garcia, Branislava Ćurčić-Blake, Sonja C. Vernes, Andrea Ravignani*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
9 Downloads (Pure)

Abstract

Comparative animal studies of complex behavioural traits, and their neurobiological underpinnings, can increase our understanding of their evolution, including in humans. Vocal learning, a potential precursor to human speech, is one such trait. Mammalian vocal learning is under-studied: most research has either focused on vocal learning in songbirds or its absence in non-human primates. Here, we focus on a highly promising model species for the neurobiology of vocal learning: grey seals (Halichoerus grypus). We provide a neuroanatomical atlas (based on dissected brain slices and magnetic resonance images), a labelled MRI template, a three-dimensional model with volumetric measurements of brain regions, and histological cortical stainings. Four main features of the grey seal brain stand out: (i) it is relatively big and highly convoluted; (ii) it hosts a relatively large temporal lobe and cerebellum; (iii) the cortex is similar to that of humans in thickness and shows the expected six-layered mammalian structure; (iv) there is expression of FoxP2 present in deeper layers of the cortex; FoxP2 is a gene involved in motor learning, vocal learning, and spoken language. Our results could facilitate future studies targeting the neural and genetic underpinnings of mammalian vocal learning, thus bridging the research gap from songbirds to humans and non-human primates. Our findings are relevant not only to vocal learning research but also to the study of mammalian neurobiology and cognition more in general.
Original languageEnglish
Article number20200252
Number of pages4
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume376
Issue number1836
Early online date6 Sept 2021
DOIs
Publication statusPublished - 25 Oct 2021

Keywords

  • Comparative neuroanatomy
  • Magnetic resonance imaging
  • FoxP2
  • Language evolution
  • Bioacoustics
  • Halichoerus grypus

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