Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

M E  Giardini; G G  Guizzetti; M  Bavera; P  Lago; A  Corti; C  Falcone; F  Pastore

doi:10.1117/12.427938

Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

M E Giardini, G G Guizzetti, M Bavera, P Lago, A Corti, C Falcone, F Pastore

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Near-Infrared Spectroscopy (NIR) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom LAIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.

Original language	English
Title of host publication	Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III
Editors	WS Grundfest, DA Benaron, T VoDinh
Place of Publication	Bellingham
Publisher	SPIE
Pages	1-6
Number of pages	6
ISBN (Print)	0-8194-3932-0
DOIs	https://doi.org/10.1117/12.427938
Publication status	Published - Jan 2001
Event	3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems - SAN JOSE Duration: 21 Jan 2001 → 22 Jan 2001

Publication series

Name	SPIE Proceedings
Volume	4254

Conference

Conference	3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems
City	SAN JOSE
Period	21/01/01 → 22/01/01

Keywords

Arteries
Cardiovascular system
Diseases and disorders
Haemodynamics
Near infrared
Spectrometers
Tissues
Transmittance
NIRS.
near-infrared spectroscopy
cardiovascular risk
CAD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.427938

Publisher final version
Mario E. Giardini, Giovanni G. Guizzetti, Matteo Bavera, Paolo Lago , Mario Corti, Colomba Falcone and Federico Pastore, "Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease" Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, Tuan Vo-Dinh, Warren S. Grundfest, David A. Benaron, Editors, Proc. SPIE 4254, 1 (2001). Copyright 2001 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.427938
Final published version, 412 KB

Cite this

Giardini, M. E., Guizzetti, G. G., Bavera, M., Lago, P., Corti, A., Falcone, C., & Pastore, F. (2001). Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease. In WS. Grundfest, DA. Benaron, & T. VoDinh (Eds.), Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III (pp. 1-6). (SPIE Proceedings; Vol. 4254). SPIE. https://doi.org/10.1117/12.427938

@inproceedings{deb4c99bdb4d4d6b87af6cc1eef11257,

title = "Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease",

abstract = "Near-Infrared Spectroscopy (NIR) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom LAIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.",

keywords = "Arteries, Cardiovascular system, Diseases and disorders, Haemodynamics, Near infrared, Spectrometers, Tissues, Transmittance, NIRS. , near-infrared spectroscopy, cardiovascular risk, CAD",

author = "Giardini, {M E} and Guizzetti, {G G} and M Bavera and P Lago and A Corti and C Falcone and F Pastore",

year = "2001",

month = jan,

doi = "10.1117/12.427938",

language = "English",

isbn = "0-8194-3932-0",

series = "SPIE Proceedings",

publisher = "SPIE",

pages = "1--6",

editor = "WS Grundfest and DA Benaron and T VoDinh",

booktitle = "Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III",

address = "United States",

note = "3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems ; Conference date: 21-01-2001 Through 22-01-2001",

}

Giardini, ME, Guizzetti, GG, Bavera, M, Lago, P, Corti, A, Falcone, C & Pastore, F 2001, Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease. in WS Grundfest, DA Benaron & T VoDinh (eds), Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III. SPIE Proceedings, vol. 4254, SPIE, Bellingham, pp. 1-6, 3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems, SAN JOSE, 21/01/01. https://doi.org/10.1117/12.427938

Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease. / Giardini, M E ; Guizzetti, G G ; Bavera, M et al.
Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III. ed. / WS Grundfest; DA Benaron; T VoDinh. Bellingham: SPIE, 2001. p. 1-6 (SPIE Proceedings; Vol. 4254).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

AU - Giardini, M E

AU - Guizzetti, G G

AU - Bavera, M

AU - Lago, P

AU - Corti, A

AU - Falcone, C

AU - Pastore, F

PY - 2001/1

Y1 - 2001/1

N2 - Near-Infrared Spectroscopy (NIR) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom LAIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.

AB - Near-Infrared Spectroscopy (NIR) can be employed to monitor local changes in haemodynamics and oxygenation of human tissues. A preliminary study has been performed in order to evaluate the NIRS transmittance response to induced forearm ischaemia in patients with coronary artery disease (CAD). The population consists in 40 patients with cardiovascular risk factors and angiographically documented CAD, compared to a group of 13 normal subjects. By inflating and subsequently deflating a cuff placed around the patient arm, an ischaemia has been induced and released, and the patients have been observed until recovery of the basal conditions. A custom LAIRS spectrometer (IRIS) has been used to collect the backscattered light intensities from the patient forearm throughout the ischaemic and the recovery phase. The time dependence of the near-infrared transmittance on the control group is consistent with the available literature. On the contrary, the magnitude and dynamics of the NIRS signal on the CAD patients show deviations from the documented normal behavior, which can be tentatively attributed to abnormal vessel stiffness. These preliminary results, while validating the performance of the IRIS spectrometer, are strongly conducive towards the applicability of the NIRS technique to ischaemia analysis and to endothelial dysfunction characterization in CAD patients with cardiovascular risk factors.

KW - Arteries

KW - Cardiovascular system

KW - Diseases and disorders

KW - Haemodynamics

KW - Near infrared

KW - Spectrometers

KW - Tissues

KW - Transmittance

KW - NIRS.

KW - near-infrared spectroscopy

KW - cardiovascular risk

KW - CAD

UR - http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=900173

U2 - 10.1117/12.427938

DO - 10.1117/12.427938

M3 - Conference contribution

SN - 0-8194-3932-0

T3 - SPIE Proceedings

SP - 1

EP - 6

BT - Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III

A2 - Grundfest, WS

A2 - Benaron, DA

A2 - VoDinh, T

PB - SPIE

CY - Bellingham

T2 - 3rd Conference on Biomedical Diagnostic, Guidance, and Surgical-Assist Systems

Y2 - 21 January 2001 through 22 January 2001

ER -

Giardini ME, Guizzetti GG, Bavera M, Lago P, Corti A, Falcone C et al. Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease. In Grundfest WS, Benaron DA, VoDinh T, editors, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III. Bellingham: SPIE. 2001. p. 1-6. (SPIE Proceedings). doi: 10.1117/12.427938

Near-infrared spectroscopy study of tourniquet-induced forearm ischaemia in patients with coronary artery disease

Abstract

Publication series

Conference

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this