Natural products incorporating pyrimidine nucleosides

Freideriki Michailidou; David Alexander Burnett; Sunil Vishnuprasadji Sharma; Steven Van Lanen; Rebecca Goss

doi:10.1016/B978-0-12-409547-2.14797-3

Natural products incorporating pyrimidine nucleosides

Freideriki Michailidou, David Alexander Burnett, Sunil Vishnuprasadji Sharma, Steven Van Lanen, Rebecca Goss

Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary

Abstract

The uridyl peptide antibiotics are a class of structurally and biologically diverse series of pyrimidine containing natural products, that have attracted considerable interest due to their powerful and varied bioactivities; and potential for exploitation in human medicine as well as agriculture.

This article overviews the varied structures of the pyrimidine nucleoside-based antibiotics, their natural origins and their bioactivities. Current understanding of the enzyme mediated assemblies (biosynthesis) of these structurally intriguing compounds is overviewed.

Original language	English
Title of host publication	Reference module in chemistry, molecular sciences and chemical engineering
Publisher	Elsevier Inc.
ISBN (Print)	9780124095472
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.14797-3
Publication status	E-pub ahead of print - 20 Feb 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-microbial
Anti-tubercular
Anti-viral
Biosynthesis of UPAs
MraY
NRPS
Nucleoside antibiotics
Pyrimidine nucleosides
Uridyl peptide antibiotics (UPAs)

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10.1016/B978-0-12-409547-2.14797-3

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title = "Natural products incorporating pyrimidine nucleosides",

abstract = "The uridyl peptide antibiotics are a class of structurally and biologically diverse series of pyrimidine containing natural products, that have attracted considerable interest due to their powerful and varied bioactivities; and potential for exploitation in human medicine as well as agriculture.This article overviews the varied structures of the pyrimidine nucleoside-based antibiotics, their natural origins and their bioactivities. Current understanding of the enzyme mediated assemblies (biosynthesis) of these structurally intriguing compounds is overviewed.",

keywords = "Anti-microbial, Anti-tubercular, Anti-viral, Biosynthesis of UPAs, MraY, NRPS, Nucleoside antibiotics, Pyrimidine nucleosides, Uridyl peptide antibiotics (UPAs)",

author = "Freideriki Michailidou and Burnett, \{David Alexander\} and Sharma, \{Sunil Vishnuprasadji\} and \{Van Lanen\}, Steven and Rebecca Goss",

year = "2020",

month = feb,

day = "20",

doi = "10.1016/B978-0-12-409547-2.14797-3",

language = "English",

isbn = "9780124095472",

booktitle = "Reference module in chemistry, molecular sciences and chemical engineering",

publisher = "Elsevier Inc.",

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TY - CHAP

T1 - Natural products incorporating pyrimidine nucleosides

AU - Michailidou, Freideriki

AU - Burnett, David Alexander

AU - Sharma, Sunil Vishnuprasadji

AU - Van Lanen, Steven

AU - Goss, Rebecca

PY - 2020/2/20

Y1 - 2020/2/20

N2 - The uridyl peptide antibiotics are a class of structurally and biologically diverse series of pyrimidine containing natural products, that have attracted considerable interest due to their powerful and varied bioactivities; and potential for exploitation in human medicine as well as agriculture.This article overviews the varied structures of the pyrimidine nucleoside-based antibiotics, their natural origins and their bioactivities. Current understanding of the enzyme mediated assemblies (biosynthesis) of these structurally intriguing compounds is overviewed.

AB - The uridyl peptide antibiotics are a class of structurally and biologically diverse series of pyrimidine containing natural products, that have attracted considerable interest due to their powerful and varied bioactivities; and potential for exploitation in human medicine as well as agriculture.This article overviews the varied structures of the pyrimidine nucleoside-based antibiotics, their natural origins and their bioactivities. Current understanding of the enzyme mediated assemblies (biosynthesis) of these structurally intriguing compounds is overviewed.

KW - Anti-microbial

KW - Anti-tubercular

KW - Anti-viral

KW - Biosynthesis of UPAs

KW - MraY

KW - NRPS

KW - Nucleoside antibiotics

KW - Pyrimidine nucleosides

KW - Uridyl peptide antibiotics (UPAs)

U2 - 10.1016/B978-0-12-409547-2.14797-3

DO - 10.1016/B978-0-12-409547-2.14797-3

M3 - Entry for encyclopedia/dictionary

SN - 9780124095472

BT - Reference module in chemistry, molecular sciences and chemical engineering

PB - Elsevier Inc.

ER -

Natural products incorporating pyrimidine nucleosides

Abstract

UN SDGs

Keywords

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