Natural products incorporating pyrimidine nucleosides

Freideriki Michailidou, David Alexander Burnett, Sunil Vishnuprasadji Sharma, Steven Van Lanen, Rebecca Goss

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionary


The uridyl peptide antibiotics are a class of structurally and biologically diverse series of pyrimidine containing natural products, that have attracted considerable interest due to their powerful and varied bioactivities; and potential for exploitation in human medicine as well as agriculture.

This article overviews the varied structures of the pyrimidine nucleoside-based antibiotics, their natural origins and their bioactivities. Current understanding of the enzyme mediated assemblies (biosynthesis) of these structurally intriguing compounds is overviewed.

Original languageEnglish
Title of host publicationReference module in chemistry, molecular sciences and chemical engineering
PublisherElsevier Inc.
ISBN (Print)9780124095472
Publication statusE-pub ahead of print - 20 Feb 2020


  • Anti-microbial
  • Anti-tubercular
  • Anti-viral
  • Biosynthesis of UPAs
  • MraY
  • NRPS
  • Nucleoside antibiotics
  • Pyrimidine nucleosides
  • Uridyl peptide antibiotics (UPAs)


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