N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

O.M. Bautista-Aguilera; A. Samadi; M. Chioua; K. Nikolic; S. Filipic; D. Agbaba; E. Soriano; L. De Andrés; M.I. Rodríguez-Franco; S. Alcaro; R.R. Ramsay; F. Ortuso; M. Yañez; J. Marco-Contelles

doi:10.1021/jm501501a

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

O.M. Bautista-Aguilera
, A. Samadi
, M. Chioua
, K. Nikolic
, S. Filipic
, D. Agbaba
, E. Soriano
, L. De Andrés
, M.I. Rodríguez-Franco
, S. Alcaro
, R.R. Ramsay
, F. Ortuso
, M. Yañez
, J. Marco-Contelles

Research output: Contribution to journal › Article › peer-review

Abstract

On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.

Original language	English
Pages (from-to)	10455-10463
Number of pages	9
Journal	Journal of Medicinal Chemistry
Volume	57
Issue number	24
Early online date	24 Nov 2014
DOIs	https://doi.org/10.1021/jm501501a
Publication status	Published - 26 Dec 2014

Keywords

Drug design
QSAR
Synthesis
Biological evaluation
Multipotent models

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bautista-aguilera2014jmedchem10455
© 2014. American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/jm501501a
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Bautista-Aguilera, O. M., Samadi, A., Chioua, M., Nikolic, K., Filipic, S., Agbaba, D., Soriano, E., De Andrés, L., Rodríguez-Franco, M. I., Alcaro, S., Ramsay, R. R., Ortuso, F., Yañez, M., & Marco-Contelles, J. (2014). N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. Journal of Medicinal Chemistry, 57(24), 10455-10463. https://doi.org/10.1021/jm501501a

@article{6cef75c9097b428784b2d432d878cfef,

title = "N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor",

abstract = "On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.",

keywords = "Drug design, QSAR, Synthesis, Biological evaluation, Multipotent models",

author = "O.M. Bautista-Aguilera and A. Samadi and M. Chioua and K. Nikolic and S. Filipic and D. Agbaba and E. Soriano and \{De Andr{\'e}s\}, L. and M.I. Rodr{\'i}guez-Franco and S. Alcaro and R.R. Ramsay and F. Ortuso and M. Ya{\~n}ez and J. Marco-Contelles",

year = "2014",

month = dec,

day = "26",

doi = "10.1021/jm501501a",

language = "English",

volume = "57",

pages = "10455--10463",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society (ACS)",

number = "24",

}

Bautista-Aguilera, OM, Samadi, A, Chioua, M, Nikolic, K, Filipic, S, Agbaba, D, Soriano, E, De Andrés, L, Rodríguez-Franco, MI, Alcaro, S, Ramsay, RR, Ortuso, F, Yañez, M & Marco-Contelles, J 2014, 'N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor', Journal of Medicinal Chemistry, vol. 57, no. 24, pp. 10455-10463. https://doi.org/10.1021/jm501501a

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. / Bautista-Aguilera, O.M.; Samadi, A.; Chioua, M. et al.
In: Journal of Medicinal Chemistry, Vol. 57, No. 24, 26.12.2014, p. 10455-10463.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

AU - Bautista-Aguilera, O.M.

AU - Samadi, A.

AU - Chioua, M.

AU - Nikolic, K.

AU - Filipic, S.

AU - Agbaba, D.

AU - Soriano, E.

AU - De Andrés, L.

AU - Rodríguez-Franco, M.I.

AU - Alcaro, S.

AU - Ramsay, R.R.

AU - Ortuso, F.

AU - Yañez, M.

AU - Marco-Contelles, J.

PY - 2014/12/26

Y1 - 2014/12/26

N2 - On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.

AB - On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.

KW - Drug design

KW - QSAR

KW - Synthesis

KW - Biological evaluation

KW - Multipotent models

UR - http://pubs.acs.org/doi/suppl/10.1021/jm501501a

U2 - 10.1021/jm501501a

DO - 10.1021/jm501501a

M3 - Article

AN - SCOPUS:84920175684

SN - 0022-2623

VL - 57

SP - 10455

EP - 10463

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 24

ER -

N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

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Keywords

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