N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor

O.M. Bautista-Aguilera, A. Samadi, M. Chioua, K. Nikolic, S. Filipic, D. Agbaba, E. Soriano, L. De Andrés, M.I. Rodríguez-Franco, S. Alcaro, R.R. Ramsay, F. Ortuso, M. Yañez, J. Marco-Contelles

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51 Citations (Scopus)


On the basis of N-((5-(3-(1-benzylpiperidin-4-yl)propoxy)-1-methyl-1H-indol-2-yl)methyl)-N-methylprop-2-yn-1-amine (II, ASS234) and QSAR predictions, in this work we have designed, synthesized, and evaluated a number of new indole derivatives from which we have identified N-methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine (2, MBA236) as a new cholinesterase and monoamine oxidase dual inhibitor.
Original languageEnglish
Pages (from-to)10455-10463
Number of pages9
JournalJournal of Medicinal Chemistry
Issue number24
Early online date24 Nov 2014
Publication statusPublished - 26 Dec 2014


  • Drug design
  • QSAR
  • Synthesis
  • Biological evaluation
  • Multipotent models


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