Abstract
N-Heterocyclic carbenes (NHCs) have become increasingly popular as ligands for transition metals, thanks to their remarkable successes in metathesis and cross-coupling areas. Important advances have also been achieved in organocopper chemistry. To date, the reported neutral N-heterocyclic carbene-copper(I) complexes have shown outstanding catalytic activity. In this account, we describe the application of such complexes in a variety of organic transformations.
1 Introduction
2 Copper-Hydride-Mediated Reactions
2.1 Reduction of Carbonyl Compounds
2.1.1 Activity and Scope
2.1.2 Mechanistic Considerations
2.2 Related Transformations
3 Carbene Transfer Reactions
3.1 Cyclopropanation and Insertion Reactions
3.2 Olefination Reactions
4 [3+2] Cycloaddition of Azides and Alkynes
4.1 'Click Chemistry'
4.2 Use of Internal Alkynes: Mechanistic Implications
5 Miscellaneous Reactions
6 Concluding Remarks.
Original language | English |
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Pages (from-to) | 2158-2167 |
Number of pages | 10 |
Journal | Synlett |
Issue number | 14 |
DOIs | |
Publication status | Published - 3 Sept 2007 |
Keywords
- N-heterocyclic carbene
- copper
- diazo compounds
- homogeneous catalysis
- hydrosilylation
- REDUCTIVE ALDOL REACTION
- QUATERNARY STEREOGENIC CENTERS
- CARBENE COPPER(I) COMPLEXES
- AZIDE-ALKYNE CYCLOADDITION
- ONE-POT SYNTHESIS
- CONJUGATE REDUCTION
- CARBONYL-COMPOUNDS
- ENANTIOSELECTIVE SYNTHESIS
- ASYMMETRIC-SYNTHESIS
- ETHYL DIAZOACETATE