Muscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone

Jonathan A. David, Robert M. Pitman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The soma membrane of the fast coxal depressor (Df) motoneurone of the cockroach,Periplaneta americana possesses a population of acetylcholine receptors which respond to both nicotinic and muscarinic ligands. Activation of these 'mixed' acetylcholine receptors by McN-A-343 or oxotremorine results in the generation of an inward current at potentials positive to -40 mV. A large proportion of the outward current induced by membrane depolarization in Df somata is due to a calcium-activated potassium conductance (IKCa) which shows a characteristic N-shape voltage-dependence. This N-shape of the membrane current-voltage relationship is suppressed by McN-A-343 or oxotremorine indicating that the agonist-induced inward current is due to a reduction in IKCa.

Original languageEnglish
Pages (from-to)153-156
Number of pages4
JournalBrain Research
Volume669
Issue number1
DOIs
Publication statusPublished - 9 Jan 1995

Keywords

  • Ca-dependent potassium current
  • Insect motoneurone
  • Muscarinic agonist outward current
  • Voltage-clamp

Fingerprint

Dive into the research topics of 'Muscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone'. Together they form a unique fingerprint.

Cite this