Muscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone

Jonathan A. David; Robert M. Pitman

doi:10.1016/0006-8993(94)01262-G

Muscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone

Jonathan A. David, Robert M. Pitman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The soma membrane of the fast coxal depressor (D_f) motoneurone of the cockroach,Periplaneta americana possesses a population of acetylcholine receptors which respond to both nicotinic and muscarinic ligands. Activation of these 'mixed' acetylcholine receptors by McN-A-343 or oxotremorine results in the generation of an inward current at potentials positive to -40 mV. A large proportion of the outward current induced by membrane depolarization in D_f somata is due to a calcium-activated potassium conductance (IKC_a) which shows a characteristic N-shape voltage-dependence. This N-shape of the membrane current-voltage relationship is suppressed by McN-A-343 or oxotremorine indicating that the agonist-induced inward current is due to a reduction in IKC_a.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Brain Research
Volume	669
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(94)01262-G
Publication status	Published - 9 Jan 1995

Keywords

Ca-dependent potassium current
Insect motoneurone
Muscarinic agonist outward current
Voltage-clamp

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10.1016/0006-8993(94)01262-G

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title = "Muscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone",

abstract = "The soma membrane of the fast coxal depressor (Df) motoneurone of the cockroach,Periplaneta americana possesses a population of acetylcholine receptors which respond to both nicotinic and muscarinic ligands. Activation of these 'mixed' acetylcholine receptors by McN-A-343 or oxotremorine results in the generation of an inward current at potentials positive to -40 mV. A large proportion of the outward current induced by membrane depolarization in Df somata is due to a calcium-activated potassium conductance (IKCa) which shows a characteristic N-shape voltage-dependence. This N-shape of the membrane current-voltage relationship is suppressed by McN-A-343 or oxotremorine indicating that the agonist-induced inward current is due to a reduction in IKCa.",

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AU - David, Jonathan A.

AU - Pitman, Robert M.

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N2 - The soma membrane of the fast coxal depressor (Df) motoneurone of the cockroach,Periplaneta americana possesses a population of acetylcholine receptors which respond to both nicotinic and muscarinic ligands. Activation of these 'mixed' acetylcholine receptors by McN-A-343 or oxotremorine results in the generation of an inward current at potentials positive to -40 mV. A large proportion of the outward current induced by membrane depolarization in Df somata is due to a calcium-activated potassium conductance (IKCa) which shows a characteristic N-shape voltage-dependence. This N-shape of the membrane current-voltage relationship is suppressed by McN-A-343 or oxotremorine indicating that the agonist-induced inward current is due to a reduction in IKCa.

AB - The soma membrane of the fast coxal depressor (Df) motoneurone of the cockroach,Periplaneta americana possesses a population of acetylcholine receptors which respond to both nicotinic and muscarinic ligands. Activation of these 'mixed' acetylcholine receptors by McN-A-343 or oxotremorine results in the generation of an inward current at potentials positive to -40 mV. A large proportion of the outward current induced by membrane depolarization in Df somata is due to a calcium-activated potassium conductance (IKCa) which shows a characteristic N-shape voltage-dependence. This N-shape of the membrane current-voltage relationship is suppressed by McN-A-343 or oxotremorine indicating that the agonist-induced inward current is due to a reduction in IKCa.

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KW - Muscarinic agonist outward current

KW - Voltage-clamp

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Muscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone

Abstract

Keywords

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