Multiscale modelling of cancer progression and treatment control: the role of intracellular heterogeneities in chemotherapy treatment

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Cancer is a complex, multiscale process involving interactions at intracellular, intercellular and tissue scales that are in turn susceptible to microenvironmental changes. Each individual cancer cell within a cancer cell mass is unique, with its own internal cellular pathways and biochemical interactions. These interactions contribute to the functional changes at the cellular and tissue scale, creating a heterogenous cancer cell population. Anticancer drugs are effective in controlling cancer growth by inflicting damage to various target molecules and thereby triggering multiple cellular and intracellular pathways, leading to cell death or cell-cycle arrest. One of the major impediments in the chemotherapy treatment of cancer is drug resistance driven by multiple mechanisms, including multi-drug and cell-cycle mediated resistance to chemotherapy drugs. In this article, we discuss two hybrid multiscale modelling approaches, incorporating multiple interactions involved in the sub-cellular, cellular and microenvironmental levels to study the effects of cell-cycle, phase-specific chemotherapy on the growth and progression of cancer cells.
Original languageEnglish
Pages (from-to)97-114
JournalBiophysical Reviews and Letters
Volume10
Issue number2
Early online date30 Apr 2015
DOIs
Publication statusPublished - Jun 2015

Keywords

  • Multiscale modelling
  • Cell-cycle pathway
  • Hypoxia
  • Chemotherapy

Fingerprint

Dive into the research topics of 'Multiscale modelling of cancer progression and treatment control: the role of intracellular heterogeneities in chemotherapy treatment'. Together they form a unique fingerprint.

Cite this