Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Alistair Craig McKinlay; Phoebe Allan; Catherine Louise Renouf; Morven Jane Duncan; Paul Stewart Wheatley; Stewart James Warrender; Daniel McLean Dawson; Sharon Elizabeth Ashbrook; Barbara Gil; Bartosz Marszalek; Tina  Düren; Jennifer J.  Williams; Cedric Charrier; Derry K.  Mercer; Simon J.  Teat; Russell Edward Morris

doi:10.1063/1.4903290

Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Alistair Craig McKinlay, Phoebe Allan, Catherine Louise Renouf, Morven Jane Duncan, Paul Stewart Wheatley, Stewart James Warrender, Daniel McLean Dawson, Sharon Elizabeth Ashbrook, Barbara Gil, Bartosz Marszalek, Tina Düren, Jennifer J. Williams, Cedric Charrier, Derry K. Mercer, Simon J. Teat, Russell Edward Morris

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58 Citations (Scopus)

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Abstract

The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

Original language	English
Article number	124108
Journal	APL Materials
Volume	2
Issue number	12
Early online date	11 Dec 2014
DOIs	https://doi.org/10.1063/1.4903290
Publication status	Published - Dec 2014

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10.1063/1.4903290

Morris_2014_APlMat_Multirate
© 2014 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/)
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Assembly Disassembly Reassembly: Assembly disassembly reassembly - New routes to extended structures and their impact
Morris, R. E. (PI)
EPSRC
1/08/13 → 31/07/18
Project: Fellowship
Hemilabile switchable metal-organic: Hemilabile and switchable metal-organic frameworks
Morris, R. E. (PI)
EPSRC
1/03/13 → 28/02/16
Project: Standard
Non-classic Crystal Growth: Non-classic Crystal Growth and New Catalysts
Zhou, W. (PI)
British Council
1/12/12 → 31/12/14
Project: Standard

Cite this

McKinlay, A. C., Allan, P., Renouf, C. L., Duncan, M. J., Wheatley, P. S., Warrender, S. J., Dawson, D. M., Ashbrook, S. E., Gil, B., Marszalek, B., Düren, T., Williams, J. J., Charrier, C., Mercer, D. K., Teat, S. J., & Morris, R. E. (2014). Multirate delivery of multiple therapeutic agents from metal-organic frameworks. APL Materials, 2(12), Article 124108. https://doi.org/10.1063/1.4903290

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title = "Multirate delivery of multiple therapeutic agents from metal-organic frameworks",

abstract = "The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.",

author = "McKinlay, {Alistair Craig} and Phoebe Allan and Renouf, {Catherine Louise} and Duncan, {Morven Jane} and Wheatley, {Paul Stewart} and Warrender, {Stewart James} and Dawson, {Daniel McLean} and Ashbrook, {Sharon Elizabeth} and Barbara Gil and Bartosz Marszalek and Tina D{\"u}ren and Williams, {Jennifer J.} and Cedric Charrier and Mercer, {Derry K.} and Teat, {Simon J.} and Morris, {Russell Edward}",

note = "REM is a Royal Society Industry Fellow and thanks the Royal Society for the provision of the Brian Mercer Award for Innovation, and thanks Scottish Enterprise for support. REM also thanks the British Heart Foundation for a New Horizons Award (NH/11/8/29253). REM and TD thank the EPSRC for funding (EP/K025112/1 and EP/K005499/1). ",

year = "2014",

month = dec,

doi = "10.1063/1.4903290",

language = "English",

volume = "2",

journal = "APL Materials",

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publisher = "American Institute of Physics",

number = "12",

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T1 - Multirate delivery of multiple therapeutic agents from metal-organic frameworks

AU - McKinlay, Alistair Craig

AU - Allan, Phoebe

AU - Renouf, Catherine Louise

AU - Duncan, Morven Jane

AU - Wheatley, Paul Stewart

AU - Warrender, Stewart James

AU - Dawson, Daniel McLean

AU - Ashbrook, Sharon Elizabeth

AU - Gil, Barbara

AU - Marszalek, Bartosz

AU - Düren, Tina

AU - Williams, Jennifer J.

AU - Charrier, Cedric

AU - Mercer, Derry K.

AU - Teat, Simon J.

AU - Morris, Russell Edward

N1 - REM is a Royal Society Industry Fellow and thanks the Royal Society for the provision of the Brian Mercer Award for Innovation, and thanks Scottish Enterprise for support. REM also thanks the British Heart Foundation for a New Horizons Award (NH/11/8/29253). REM and TD thank the EPSRC for funding (EP/K025112/1 and EP/K005499/1).

PY - 2014/12

Y1 - 2014/12

N2 - The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

AB - The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria.

U2 - 10.1063/1.4903290

DO - 10.1063/1.4903290

M3 - Article

SN - 2166-532X

VL - 2

JO - APL Materials

JF - APL Materials

IS - 12

M1 - 124108

ER -

Multirate delivery of multiple therapeutic agents from metal-organic frameworks

Abstract

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Projects

Assembly Disassembly Reassembly: Assembly disassembly reassembly - New routes to extended structures and their impact

Hemilabile switchable metal-organic: Hemilabile and switchable metal-organic frameworks

Non-classic Crystal Growth: Non-classic Crystal Growth and New Catalysts

Cite this