Multi-vicinal fluoroalkanes:  a new class of organofluorine compounds

Luke Hunter; David O'Hagan

doi:10.1039/b809432b

Multi-vicinal fluoroalkanes: a new class of organofluorine compounds

Luke Hunter, David O'Hagan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

"Multi-vicinal fluoroalkanes" are straight-chain alkanes in which each adjacent carbon atom is bonded to one fluorine atom. Such molecules may be regarded as intermediate in structure between alkanes and perfluoroalkanes. The alternate fluoromethylene groups also generate stereogenic centres, which need to be controlled during synthesis. This review will describe our recent progress in the preparation of such single isomer motifs and the Study of the conformational behaviour of this new class of organofluorine compounds.

Original language	English
Pages (from-to)	2843-2848
Number of pages	6
Journal	Organic & Biomolecular Chemistry
Volume	6
Issue number	16
DOIs	https://doi.org/10.1039/b809432b
Publication status	Published - 21 Aug 2008

Keywords

PEPTIDASE-IV INHIBITORS
LIQUID-CRYSTALS
SPECTRUM DEOXOFLUORINATING AGENT
DERIVATIVES
BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE
ENHANCED THERMAL-STABILITY
CONFORMATION
EPOXIDES
DIASTEREOISOMERS
FLUORINATION

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10.1039/b809432b

Synthesis and properties of novel sequen: Synthesis and properties of novel sequentially fluorinated motifs in organcic chemistry
O'Hagan, D. (PI)
EPSRC
24/03/08 → 23/03/11
Project: Standard
EP/C536037/1: Advanced Biophotonics Workstation
Riches, A. C. (PI), Dholakia, K. (CoI), Gunn-Moore, F. J. (CoI) & Sibbett, W. (CoI)
EPSRC
1/10/05 → 30/09/09
Project: Standard
EP/C536037/1: Advanced Biophotonics Workstation
Dholakia, K. (PI), Gunn-Moore, F. J. (CoI), Riches, A. C. (CoI) & Sibbett, W. (CoI)
EPSRC
1/10/05 → 30/09/09
Project: Standard

Cite this

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title = "Multi-vicinal fluoroalkanes: a new class of organofluorine compounds",

abstract = "{"}Multi-vicinal fluoroalkanes{"} are straight-chain alkanes in which each adjacent carbon atom is bonded to one fluorine atom. Such molecules may be regarded as intermediate in structure between alkanes and perfluoroalkanes. The alternate fluoromethylene groups also generate stereogenic centres, which need to be controlled during synthesis. This review will describe our recent progress in the preparation of such single isomer motifs and the Study of the conformational behaviour of this new class of organofluorine compounds.",

keywords = "PEPTIDASE-IV INHIBITORS, LIQUID-CRYSTALS, SPECTRUM DEOXOFLUORINATING AGENT, DERIVATIVES, BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE, ENHANCED THERMAL-STABILITY, CONFORMATION, EPOXIDES, DIASTEREOISOMERS, FLUORINATION",

author = "Luke Hunter and David O'Hagan",

year = "2008",

month = aug,

day = "21",

doi = "10.1039/b809432b",

language = "English",

volume = "6",

pages = "2843--2848",

journal = "Organic & Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "16",

}

TY - JOUR

T1 - Multi-vicinal fluoroalkanes

T2 - a new class of organofluorine compounds

AU - Hunter, Luke

AU - O'Hagan, David

PY - 2008/8/21

Y1 - 2008/8/21

N2 - "Multi-vicinal fluoroalkanes" are straight-chain alkanes in which each adjacent carbon atom is bonded to one fluorine atom. Such molecules may be regarded as intermediate in structure between alkanes and perfluoroalkanes. The alternate fluoromethylene groups also generate stereogenic centres, which need to be controlled during synthesis. This review will describe our recent progress in the preparation of such single isomer motifs and the Study of the conformational behaviour of this new class of organofluorine compounds.

AB - "Multi-vicinal fluoroalkanes" are straight-chain alkanes in which each adjacent carbon atom is bonded to one fluorine atom. Such molecules may be regarded as intermediate in structure between alkanes and perfluoroalkanes. The alternate fluoromethylene groups also generate stereogenic centres, which need to be controlled during synthesis. This review will describe our recent progress in the preparation of such single isomer motifs and the Study of the conformational behaviour of this new class of organofluorine compounds.

KW - PEPTIDASE-IV INHIBITORS

KW - LIQUID-CRYSTALS

KW - SPECTRUM DEOXOFLUORINATING AGENT

KW - DERIVATIVES

KW - BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE

KW - ENHANCED THERMAL-STABILITY

KW - CONFORMATION

KW - EPOXIDES

KW - DIASTEREOISOMERS

KW - FLUORINATION

U2 - 10.1039/b809432b

DO - 10.1039/b809432b

M3 - Article

SN - 1477-0520

VL - 6

SP - 2843

EP - 2848

JO - Organic & Biomolecular Chemistry

JF - Organic & Biomolecular Chemistry

IS - 16

ER -

Multi-vicinal fluoroalkanes: a new class of organofluorine compounds

Abstract

Keywords

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Projects

Synthesis and properties of novel sequen: Synthesis and properties of novel sequentially fluorinated motifs in organcic chemistry

EP/C536037/1: Advanced Biophotonics Workstation

EP/C536037/1: Advanced Biophotonics Workstation

Cite this