Multi-part balanced incomplete-block designs

R. A. Bailey; Peter J. Cameron

doi:10.1007/s00362-018-01071-x

Multi-part balanced incomplete-block designs

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Abstract

We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some consequences. Then we give several different constructions. Finally we generalize this to three or more factors, such as biomarkers.

Original language	English
Pages (from-to)	405-426
Number of pages	22
Journal	Statistical Papers
Volume	60
Issue number	2
Early online date	23 Jan 2019
DOIs	https://doi.org/10.1007/s00362-018-01071-x
Publication status	Published - 18 Apr 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Balanced incomplete-block design
Basket trial
Multi-part design
Orthogonal array
Orthogonal multi-array

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Bailey-Cameron2019_Article_Multi-partBalancedIncomplete-b
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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title = "Multi-part balanced incomplete-block designs",

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AB - We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some consequences. Then we give several different constructions. Finally we generalize this to three or more factors, such as biomarkers.

KW - Balanced incomplete-block design

KW - Basket trial

KW - Multi-part design

KW - Orthogonal array

KW - Orthogonal multi-array

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Multi-part balanced incomplete-block designs

Abstract

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Keywords

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