Multi-part balanced incomplete-block designs

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We consider designs for cancer trials which allow each medical centre to treat only a limited number of cancer types with only a limited number of drugs. We specify desirable properties of these designs, and prove some consequences. Then we give several different constructions. Finally we generalize this to three or more factors, such as biomarkers.
Original languageEnglish
Pages (from-to)405-426
Number of pages22
JournalStatistical Papers
Volume60
Issue number2
Early online date23 Jan 2019
DOIs
Publication statusPublished - 18 Apr 2019

Keywords

  • Balanced incomplete-block design
  • Basket trial
  • Multi-part design
  • Orthogonal array
  • Orthogonal multi-array

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