Multi-layered genome defences in bacteria

Aleksei Agapov; Kate S. Baker; Paritosh Bedekar; Rama P. Bhatia; Tim R. Blower; Michael A. Brockhurst; Cooper Brown; Charlotte E. Chong; Joanne L. Fothergill; Shirley Graham; James PJ Hall; Alice Maestri; Stuart McQuarrie; Anna Olina; Stefano Pagliara; Mario Recker; Anna Richmond; Steven J. Shaw; Mark D. Szczelkun; Tiffany B. Taylor; Stineke van Houte; Sam C. Went; Edze R. Westra; Malcolm F. White; Rosanna Wright

doi:10.1016/j.mib.2024.102436

Multi-layered genome defences in bacteria

Aleksei Agapov
, Kate S. Baker
, Paritosh Bedekar
, Rama P. Bhatia
, Tim R. Blower
, Michael A. Brockhurst
, Cooper Brown
, Charlotte E. Chong
, Joanne L. Fothergill
, Shirley Graham
, James PJ Hall
, Alice Maestri
, Stuart McQuarrie
, Anna Olina
, Stefano Pagliara
, Mario Recker
, Anna Richmond
, Steven J. Shaw
, Mark D. Szczelkun
, Tiffany B. Taylor

Stineke van Houte, Sam C. Went, Edze R. Westra^*, Malcolm F. White, Rosanna Wright

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

Original language	English
Article number	102436
Number of pages	10
Journal	Current Opinion in Microbiology
Volume	78
Early online date	17 Feb 2024
DOIs	https://doi.org/10.1016/j.mib.2024.102436
Publication status	Published - 1 Apr 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.mib.2024.102436Licence: CC BY

Agapov_2024_COM_Multi-layered-geenome_CC
Copyright © 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 3.17 MBLicence: CC BY

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Multi-layered bacterial genome defences: Multi-layered bacterial genome defences: linking molecular mechanisms to bacteria-MGE conflicts in single cells, populations, and communities.
White, M. (PI)
Biotechnology and Biological Sciences Research Council
1/01/23 → 31/07/27
Project: Standard

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Agapov, A., Baker, K. S., Bedekar, P., Bhatia, R. P., Blower, T. R., Brockhurst, M. A., Brown, C., Chong, C. E., Fothergill, J. L., Graham, S., Hall, J. PJ., Maestri, A., McQuarrie, S., Olina, A., Pagliara, S., Recker, M., Richmond, A., Shaw, S. J., Szczelkun, M. D., ... Wright, R. (2024). Multi-layered genome defences in bacteria. Current Opinion in Microbiology, 78, Article 102436. https://doi.org/10.1016/j.mib.2024.102436

@article{a8de3f85df724d40b2459eb1e2835fbc,

title = "Multi-layered genome defences in bacteria",

abstract = "Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR{\textendash}Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels. ",

author = "Aleksei Agapov and Baker, \{Kate S.\} and Paritosh Bedekar and Bhatia, \{Rama P.\} and Blower, \{Tim R.\} and Brockhurst, \{Michael A.\} and Cooper Brown and Chong, \{Charlotte E.\} and Fothergill, \{Joanne L.\} and Shirley Graham and Hall, \{James PJ\} and Alice Maestri and Stuart McQuarrie and Anna Olina and Stefano Pagliara and Mario Recker and Anna Richmond and Shaw, \{Steven J.\} and Szczelkun, \{Mark D.\} and Taylor, \{Tiffany B.\} and \{van Houte\}, Stineke and Went, \{Sam C.\} and Westra, \{Edze R.\} and White, \{Malcolm F.\} and Rosanna Wright",

note = "This work was supported by a grant from the Biotechnology and Biological Sciences Research Council sLoLa BB/X003051/1 , awarded to KB, TRB, MB, JF, JH, SP, MR, MDS, TBT, SVH, ERW and MFW. JH is supported by an MRC Career Development Award ( MR/W02666X/1 ). AA is supported by UK Research and Innovation under the UK government{\textquoteright}s Horizon Europe funding guarantee ( EP/Y020308/1 ).",

year = "2024",

month = apr,

day = "1",

doi = "10.1016/j.mib.2024.102436",

language = "English",

volume = "78",

journal = "Current Opinion in Microbiology",

issn = "1369-5274",

publisher = "Elsevier",

}

Agapov, A, Baker, KS, Bedekar, P, Bhatia, RP, Blower, TR, Brockhurst, MA, Brown, C, Chong, CE, Fothergill, JL, Graham, S, Hall, JPJ, Maestri, A, McQuarrie, S, Olina, A, Pagliara, S, Recker, M, Richmond, A, Shaw, SJ, Szczelkun, MD, Taylor, TB, van Houte, S, Went, SC, Westra, ER, White, MF & Wright, R 2024, 'Multi-layered genome defences in bacteria', Current Opinion in Microbiology, vol. 78, 102436. https://doi.org/10.1016/j.mib.2024.102436

TY - JOUR

T1 - Multi-layered genome defences in bacteria

AU - Agapov, Aleksei

AU - Baker, Kate S.

AU - Bedekar, Paritosh

AU - Bhatia, Rama P.

AU - Blower, Tim R.

AU - Brockhurst, Michael A.

AU - Brown, Cooper

AU - Chong, Charlotte E.

AU - Fothergill, Joanne L.

AU - Graham, Shirley

AU - Hall, James PJ

AU - Maestri, Alice

AU - McQuarrie, Stuart

AU - Olina, Anna

AU - Pagliara, Stefano

AU - Recker, Mario

AU - Richmond, Anna

AU - Shaw, Steven J.

AU - Szczelkun, Mark D.

AU - Taylor, Tiffany B.

AU - van Houte, Stineke

AU - Went, Sam C.

AU - Westra, Edze R.

AU - White, Malcolm F.

AU - Wright, Rosanna

N1 - This work was supported by a grant from the Biotechnology and Biological Sciences Research Council sLoLa BB/X003051/1 , awarded to KB, TRB, MB, JF, JH, SP, MR, MDS, TBT, SVH, ERW and MFW. JH is supported by an MRC Career Development Award ( MR/W02666X/1 ). AA is supported by UK Research and Innovation under the UK government’s Horizon Europe funding guarantee ( EP/Y020308/1 ).

PY - 2024/4/1

Y1 - 2024/4/1

N2 - Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

AB - Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR–Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

U2 - 10.1016/j.mib.2024.102436

DO - 10.1016/j.mib.2024.102436

M3 - Review article

C2 - 38368839

AN - SCOPUS:85185407446

SN - 1369-5274

VL - 78

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

M1 - 102436

ER -

Multi-layered genome defences in bacteria

Abstract

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Multi-layered bacterial genome defences: Multi-layered bacterial genome defences: linking molecular mechanisms to bacteria-MGE conflicts in single cells, populations, and communities.

Cite this