Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations

S Bader; M Walker; D Harrison

doi:10.1054/bjoc.2000.1482

Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations

S Bader, M Walker, D Harrison

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.

Original language	English
Pages (from-to)	1646-1649
Number of pages	4
Journal	British Journal of Cancer
Volume	83
Issue number	12
Early online date	5 Dec 2000
DOIs	https://doi.org/10.1054/bjoc.2000.1482
Publication status	Published - 2000

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

MBD4
Colorectal cancer
Microsatellite instability

Access to Document

10.1054/bjoc.2000.1482

bader2000bjc1646
© 2000 Cancer Research Campaign. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
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title = "Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations",

abstract = "The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.",

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T1 - Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations

AU - Bader, S

AU - Walker, M

AU - Harrison, D

PY - 2000

Y1 - 2000

N2 - The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.

AB - The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.

KW - MBD4

KW - Colorectal cancer

KW - Microsatellite instability

UR - http://www.nature.com/bjc/journal/v83/n12/full/6691482a.html

UR - https://www.scopus.com/pages/publications/0034543135

U2 - 10.1054/bjoc.2000.1482

DO - 10.1054/bjoc.2000.1482

M3 - Article

SN - 0007-0920

VL - 83

SP - 1646

EP - 1649

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 12

ER -

Most microsatellite unstable sporadic colorectal carcinomas carry MBD4 mutations

Abstract

UN SDGs

Keywords

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