Abstract
The MBD4 gene is involved in the repair of mutation at methyl-CpG dinucleotides. In microsatellite unstable tumours MBD4 can itself be mutated at an exonic polynucleotide tract. By analysing DNA from microdissected tumour samples we have found that both frequency and pattern of mutation are more significant than originally reported.
| Original language | English |
|---|---|
| Pages (from-to) | 1646-1649 |
| Number of pages | 4 |
| Journal | British Journal of Cancer |
| Volume | 83 |
| Issue number | 12 |
| Early online date | 5 Dec 2000 |
| DOIs | |
| Publication status | Published - 2000 |
Keywords
- MBD4
- Colorectal cancer
- Microsatellite instability
Access to Document
- bader2000bjc1646
© 2000 Cancer Research Campaign. From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/