Monte Carlo modelling of photodynamic therapy treatments comparing clustered three dimensional tumour structures with homogeneous tissue structures

C. L. Campbell, K. Wood, C. T. A. Brown, H. Moseley

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

We explore the effects of three dimensional (3D) tumour structures on depth dependent fluence rates, photodynamic doses (PDD) and fluorescence images through Monte Carlo radiation transfer modelling of photodynamic therapy. The aim with this work was to compare the commonly used uniform tumour densities with non-uniform densities to determine the importance of including 3D models in theoretical investigations. It was found that fractal 3D models resulted in deeper penetration on average of therapeutic radiation and higher PDD. An increase in effective treatment depth of 1 mm was observed for one of the investigated fractal structures, when comparing to the equivalent smooth model. Wide field fluorescence images were simulated, revealing information about the relationship between tumour structure and the appearance of the fluorescence intensity. Our models indicate that the 3D tumour structure strongly affects the spatial distribution of therapeutic light, the PDD and the wide field appearance of surface fluorescence images.
Original languageEnglish
Pages (from-to)4840-4854
Number of pages15
JournalPhysics in Medicine and Biology
Volume61
Issue number13
Early online date7 Jun 2016
DOIs
Publication statusPublished - 7 Jul 2016

Keywords

  • Monte Carlo modelling
  • Photodynamic therapy
  • Three dimensional modelling

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