Monoamine oxidases: Old friends hold many surprises

T. P. Singer*, R. R. Ramsay

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

70 Citations (Scopus)

Abstract

The two forms of monoamine oxidase (MAO), A and B, continue to be of major interest to biochemists, pharmacologists, neurologists, and gerontologists. Despite intensive study for more than half a century, unexpected and unique properties of these enzymes continue to come to light. Recent studies have centered on their kinetic mechanism, their unique predilection for substrates related to the neurotoxic tertiary amine MPTP, and their putative role in aging and in the etiology of neurodegenerative diseases. New and potent inhibitors of MAO A and MAO B continue to be developed because of their potential use in clinical medicine. Some are effective in the picomolar range but MAO B from different mammalian species shows remarkable differences in sensitivity to these agents.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalFASEB Journal
Volume9
Issue number8
Publication statusPublished - 1 Jan 1995

Keywords

  • aging
  • inhibitors
  • Parkinson's disease

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